Abnormal thyroid function tests in children on ethionamide treatment

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dc.contributor.authorThee S.
dc.contributor.authorZollner E.W.
dc.contributor.authorWillemse M.
dc.contributor.authorHesseling A.C.
dc.contributor.authorMagdorf K.
dc.contributor.authorSchaaf H.S.
dc.date.accessioned2011-10-13T16:58:14Z
dc.date.available2011-10-13T16:58:14Z
dc.date.issued2011
dc.description.abstractEthionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children: elevated serum TSH and suppressed fT4 (n = 30), isolated elevated serum TSH (n = 20), isolated low serum fT4 (n = 28) and isolated low TSH (n = 1). The risk for biochemical hypothyroidism was higher for children on regimens including para-aminosalicylic acid and in human immunodefi ciency virus infected children. TFT abnormalities are frequent in children on ETH and are mainly due to primary hypothyroidism or euthyroid sick syndrome. © 2011 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation15
dc.identifier.citation9
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80051677011&partnerID=40&md5=a953a22a34c04b77b76745e7004842bc
dc.identifier.issn10273719
dc.identifier.other10.5588/ijtld.10.0707
dc.identifier.urihttp://hdl.handle.net/10019.1/16655
dc.subjectChildren
dc.subjectEthionamide
dc.subjectThyroid function
dc.subjectTuberculosis
dc.subjectaminosalicylic acid
dc.subjectethionamide
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjectadolescent
dc.subjectarticle
dc.subjectbiochemistry
dc.subjectchild
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectextrapulmonary tuberculosis
dc.subjectfemale
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjecthypothyroidism
dc.subjectinfant
dc.subjectlung tuberculosis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjectside effect
dc.subjectthyroid function test
dc.subjectthyrotropin blood level
dc.subjectthyroxine blood level
dc.subjecttuberculous lymphadenitis
dc.subjecttuberculous meningitis
dc.titleAbnormal thyroid function tests in children on ethionamide treatment
dc.typeArticle
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