Flux balance analysis of Plasmodium falciparum growth and energy metabolism

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dc.contributor.advisorSnoep, Jacky L.en_ZA
dc.contributor.advisorEicher, J.en_ZA
dc.contributor.authorBurger, Robert Williamen_ZA
dc.contributor.otherStellenbosch University. Faculty of Science. Dept. of Biochemistry.en_ZA
dc.date.accessioned2017-11-22T12:11:13Z
dc.date.accessioned2017-12-11T10:30:05Z
dc.date.available2018-05-22T03:00:05Z
dc.date.issued2017-12
dc.descriptionThesis (MSc)--Stellenbosch University, 2017.en_ZA
dc.description.abstractENGLISH ABSTRACT: Genome-scale network reconstructions serve as an ideal tool for the modeling of large, complex metabolic networks. In this study we use ux-balance analysis to investigate key amino acid dependencies of Plasmodium falciparum growth. Our model was able to produce a realistic ux distribution geared for the optimal production of biomass. We were able to simulate parasite growth in a variety of conditions and assess the favourability of these conditions for optimal growth. To demonstrate the applicability of the model we additionally simulate the response of the model to the introduction of an antimalarial agent, atovaquone.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.embargo.terms2018-05-22
dc.format.extent104 pages : illustrationsen_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/102598
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subjectFlux balance analysisen_ZA
dc.subjectPlasmodium falciparumen_ZA
dc.subjectMetabolic network amino aciden_ZA
dc.subjectMetabolism of Plasmodium falciparumen_ZA
dc.subjectUCTDen_ZA
dc.titleFlux balance analysis of Plasmodium falciparum growth and energy metabolismen_ZA
dc.typeThesisen_ZA
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