The spectrum of disease in children treated for tuberculosis in a highly endemic area

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dc.contributor.authorMarais B.J.
dc.contributor.authorGie R.P.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorHesseling A.C.
dc.contributor.authorEnarson D.A.
dc.contributor.authorBeyers N.
dc.date.accessioned2011-05-15T15:53:50Z
dc.date.available2011-05-15T15:53:50Z
dc.date.issued2006
dc.description.abstractBACKGROUND: Children contribute a substantial proportion of the global tuberculosis (TB) caseload, particularly in endemic areas, where little is known about their spectrum of disease. OBJECTIVE: To document the complete disease spectrum, with relevant age- and HIV-related differences, in children treated for TB in a highly endemic community. METHODS: A prospective descriptive study was conducted from February 2003 to October 2004 at five primary health care clinics in Cape Town, South Africa, including all children (<13 years of age) treated for TB. RESULTS: In total, 439 children received anti-tuberculosis treatment. The spectrum of disease included 85 (19.4%) 'not TB', 307 (86.7%) intra-thoracic TB and 72 (20.3%) extra-thoracic TB (25 [5.7%] with co-existing intra- and extra-thoracic disease were included in both groups). In non-HIV-infected children, disseminated (miliary) disease (9/11, 81.8%) and tuberculous meningitis (TBM) (10/13, 76.9%) were predominantly documented in children <3 years of age. In HIV-infected children, complicated Ghon focus and disseminated (miliary) disease were significantly more common (6/25, 24.0%) than in non-HIV-infected children (12/414, 2.9%) (OR 10.9, 95% CI 3.2-35.9). CONCLUSION: This study describes the complete disease spectrum observed in children treated for TB in a highly endemic area. Children suffered significant morbidity, with most severe disease recorded in very young and/or HIV-infected children. © 2006 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation10
dc.identifier.citation7
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/8839
dc.titleThe spectrum of disease in children treated for tuberculosis in a highly endemic area
dc.typeArticle
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