Predictors of mortality in adults on treatment for human immunodeficiency virus-associated tuberculosis in Botswana : a retrospective cohort study
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Health
Abstract
Mortality in patients with human immunodeficiency virus (HIV)-associated tuberculosis (TB) is high, particularly in sub-Saharan Africa.
This study aimed to compare mortality and predictors of mortality in those who were antiretroviral therapy (ART) naïve to those with
prior ART exposure.
This retrospective cohort study was conducted in Serowe/Palapye District, Botswana, a predominantly urban district with a large
burden of HIV-associated TB with a high case fatality. Between January 1, 2013 and December 31, 2013, patients confirmed with
HIV-associated TB were enrolled and followed up. Kaplan–Meier and Cox proportional hazard modeling was undertaken to identify
predictors of mortality, with ART initiation included as time-updated variable.
Among the 300 patients enrolled in the study, 131 had started ART before TB diagnosis (44%). There were 45 deaths. There was
no difference in mortality between ART-naïve patients and those with prior ART exposure. In the multivariate analysis, no ART use
during TB treatment (hazard ratio [HR]=5.6, 95% confidence interval [CI]=2.9–11; P<.001), opportunistic infections other than TB
(HR=8.5, 95% CI=4–18.4; P=.013), age ≥60 years (HR=4.8, 95% CI=1.8–13; P=.002), hemoglobin <10g/dL (HR=2.4, 95%
CI=1.3–4.5) and hepatotoxicity (HR=5, 95% CI=1.6–17; P=.007) were associated with increased mortality. In the subgroup
analysis, among ART-naïve patients, no ART use during TB treatment (HR=8.1, 95% CI=3.4–19.4; P<.001), opportunistic
infections other than TB (HR=16, 95% CI=6.2–42; P<.001), and hepatotoxicity (HR=8.3, 95% CI=2.6–27; P<.001) were
associated with mortality. Among patients with prior ART exposure, opportunistic infections other than TB (HR=6, 95% CI=2.6–27;
P<.001) were associated with mortality.
Mortality in patients with HIV-associated TB is still high. To reduce mortality, close clinical monitoring of patients together with
initiation of ART during TB treatment is indicated.
Description
CITATION: Muyaya, L. M., Young, T. & Loveday, M. 2018. Predictors of mortality in adults on treatment for human immunodeficiency virus-associated tuberculosis in Botswana: a retrospective cohort study. Medicine, 97(16):e0486, doi:10.1097/MD.0000000000010486.
The original publication is available at http://journals.lww.com/md-journal
Publication of this article was funded by the Stellenbosch University Open Access Fund.
The original publication is available at http://journals.lww.com/md-journal
Publication of this article was funded by the Stellenbosch University Open Access Fund.
Keywords
Highly active antiretroviral therapy -- Comparative method, Aids (Disease) -- Patients -- Botswana -- Mortality, HIV infections -- Patients -- Botswana -- Mortality, Tuberculosis -- Patients -- Botswana -- Mortality
Citation
Muyaya, L. M., Young, T. & Loveday, M. 2018. Predictors of mortality in adults on treatment for human immunodeficiency virus-associated tuberculosis in Botswana: a retrospective cohort study. Medicine, 97(16):e0486, doi:10.1097/MD.0000000000010486