Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions

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dc.contributor.authorCabooter D.
dc.contributor.authorLestremau F.
dc.contributor.authorde Villiers A.
dc.contributor.authorBroeckhoven K.
dc.contributor.authorLynen F.
dc.contributor.authorSandra P.
dc.contributor.authorDesmet G.
dc.date.accessioned2011-05-15T15:59:34Z
dc.date.available2011-05-15T15:59:34Z
dc.date.issued2009
dc.description.abstractThe present study investigates how strong the kinetic plot method is influenced by the changes in plate height, retention factor and apparent column permeability that arise under conditions of very high pressure. More precisely, the study investigates how well a set of performance measurements conducted on a single short column can be used to predict the performance of a long sequence of coupled columns. This has been investigated for the two practically most relevant thermal conditions, i.e., that of a forced-air oven and that of a still-air oven. Measuring column performance data for acetophenone and benzene on a series of coupled 3.5 μm columns that could be operated up to 1000 bar, it was found that the kinetic plot method provides accurate predictions of time versus efficiency for the still-air oven systems, over the entire range of investigated pressures and column lengths (up to 60 cm), provided k′ and Kv0 are evaluated at the maximal pressure. For the forced-air oven which leads to worse performances than the still-air oven, the kinetic plot prediction is less accurate, partly because the thermal conditions (near-isothermal) tend to vary if the number of coupled columns increases. The fact that the thermal conditions of the column wall might vary with the column length is an additional complexity making very-high pressure separations less predictable and harder to interpret and model. © 2009 Elsevier B.V. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Chromatography A
dc.identifier.citation1216
dc.identifier.citation18
dc.identifier.issn219673
dc.identifier.other10.1016/j.chroma.2009.02.079
dc.identifier.urihttp://hdl.handle.net/10019.1/11253
dc.subjectAdiabatic conditions
dc.subjectIsothermal conditions
dc.subjectKinetic plot method
dc.subjectUltra high pressure
dc.subjectValidation
dc.subjectBenzene
dc.subjectHigh pressure liquid chromatography
dc.subjectKetones
dc.subjectOvens
dc.subjectStoves
dc.subjectTime series
dc.subjectParticle size analysis
dc.subjectacetophenone
dc.subjectbenzene
dc.subjectaccuracy
dc.subjectarticle
dc.subjecthyperbarism
dc.subjectperformance measurement system
dc.subjectprediction
dc.subjectpriority journal
dc.subjecttemperature
dc.subjectvalidity
dc.subjectChromatography, High Pressure Liquid
dc.subjectKinetics
dc.subjectPressure
dc.subjectTemperature
dc.titleInvestigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions
dc.typeArticle
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