Changing the course of schizophrenia - Predictors of treatment outcome revisited

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dc.contributor.authorEmsley R.
dc.contributor.authorOosthulzen P.
dc.contributor.authorNiehaus D.
dc.contributor.authorKoen L.
dc.contributor.authorChiliza B.
dc.date.accessioned2011-05-15T15:57:46Z
dc.date.available2011-05-15T15:57:46Z
dc.date.issued2007
dc.description.abstractMultiple factors play a role in determining the outcome of schizophrenia. However, the role of these factors is poorly understood, and research findings so far have been inconclusive and sometimes contradictory. Various demographic and baseline clinical factors have been reported to be associated with treatment outcome. Also, early symptom reduction after initiation of antipsychotic therapy is closely related to later treatment response. However, associations as such do not necessarily imply predictive value, and none of these factors can be regarded as clinically useful in predicting treatment outcome. This article discusses selected aspects of treatment outcome and its prediction in schizophrenia, focusing particularly on early treatment response, ethnicity, neurological soft signs, and the predictive value of a discriminant functional analysis model utilising a combination of putative predictors. Such a model holds promise, and it is to be hoped that future refinements will lead to a clinically useful model for predicting outcome.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Psychiatry
dc.identifier.citation13
dc.identifier.citation1
dc.identifier.issn16089685
dc.identifier.urihttp://hdl.handle.net/10019.1/10585
dc.subjectatypical antipsychotic agent
dc.subjecthaloperidol
dc.subjectneuroleptic agent
dc.subjectolanzapine
dc.subjectplacebo
dc.subjectrisperidone
dc.subjectarticle
dc.subjectattention
dc.subjectclinical trial
dc.subjectcognitive defect
dc.subjectcomorbidity
dc.subjectdepression
dc.subjectdiscriminant analysis
dc.subjectdisease association
dc.subjectdisease course
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectdrug blood level
dc.subjectdrug efficacy
dc.subjectdrug formulation
dc.subjectearly intervention
dc.subjectethnic difference
dc.subjectethnicity
dc.subjectextrapyramidal symptom
dc.subjectgenetic polymorphism
dc.subjecthealth care access
dc.subjecthospital readmission
dc.subjecthuman
dc.subjectmental health care
dc.subjectmeta analysis
dc.subjectneurologic disease
dc.subjectparkinsonism
dc.subjectpatient compliance
dc.subjectprediction
dc.subjectrelapse
dc.subjectremission
dc.subjectrisk reduction
dc.subjectschizophrenia
dc.subjectsex difference
dc.subjectsubstance abuse
dc.subjectsystematic review
dc.subjecttardive dyskinesia
dc.subjecttreatment outcome
dc.subjecttreatment response
dc.titleChanging the course of schizophrenia - Predictors of treatment outcome revisited
dc.typeArticle
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