Clinicopathological features of Meckel's diverticula in 32 patients, with emphasis on the presence of Helicobacter pylori

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dc.contributor.authorEdge J.M.
dc.contributor.authorSchneider J.W.
dc.contributor.authorMoore S.W.
dc.date.accessioned2011-05-15T15:57:54Z
dc.date.available2011-05-15T15:57:54Z
dc.date.issued2001
dc.description.abstractMeckel's diverticula (MD) with areas of gastric heterotopia (metaplasia) are more likely to become symptomatic than those that contain mucosa of purely an intestinal type. Helicobacter pylori has been associated with the pathogenesis of various diseases. The aim of the study was to evaluate whether H. pylori could be identified within metaplastic gastric mucosa in MD. A retrospective evaluation of the histopathological features and the clinical presentation of patients with MD was undertaken. The study group included 32 cases (20 paediatric and 12 adults). The commonest modes of presentation were acute pain (25%), obstruction (19%), bleeding (12.5%) and hernias (9%). On histological examination, heterotopic gastric mucosa was noted to be present in 12 cases. Of these, 3 specimens were noted to have H. pylori organisms present using a specific immunostaining technique. Two patients had concurrent gastric biopsies; one stained positively for H. pylori but the second (1 mm biopsy) was rapid urease-test positive only. In conclusion, the study provides strong evidence that H. pylori may colonise heterotopic gastric mucosa in a minority of MD. H. pylori is apparently not involved in the pathogenesis of most cases of complicated MD. Nonetheless, all 3 patients who had evidence of H. pylori were symptomatic.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Surgery
dc.identifier.citation39
dc.identifier.citation3
dc.identifier.issn382361
dc.identifier.urihttp://hdl.handle.net/10019.1/10664
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectbacterium identification
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectectopic stomach mucosa
dc.subjectfemale
dc.subjectgastrointestinal hemorrhage
dc.subjectHelicobacter pylori
dc.subjecthistopathology
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectinguinal hernia
dc.subjectintestine obstruction
dc.subjectlymphoid hyperplasia
dc.subjectmale
dc.subjectMeckel diverticulum
dc.subjectpain
dc.subjectsmall intestine resection
dc.subjectAdolescent
dc.subjectFemale
dc.subjectGastric Mucosa
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectMale
dc.subjectMeckel Diverticulum
dc.subjectRetrospective Studies
dc.titleClinicopathological features of Meckel's diverticula in 32 patients, with emphasis on the presence of Helicobacter pylori
dc.typeArticle
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