Association between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene
dc.contributor.author | Rossouw M. | |
dc.contributor.author | Nel H.J. | |
dc.contributor.author | Cooke G.S. | |
dc.contributor.author | Van Helden P.D. | |
dc.contributor.author | Hoal E.G. | |
dc.date.accessioned | 2011-05-15T15:57:03Z | |
dc.date.available | 2011-05-15T15:57:03Z | |
dc.date.issued | 2003 | |
dc.description.abstract | Interferon γ is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon γ (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A→T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFκB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon γ and expression might be important for the development of tuberculosis. | |
dc.description.version | Article | |
dc.identifier.citation | Lancet | |
dc.identifier.citation | 361 | |
dc.identifier.citation | 9372 | |
dc.identifier.issn | 1406736 | |
dc.identifier.other | 10.1016/S0140-6736(03)13491-5 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/10188 | |
dc.subject | DNA | |
dc.subject | gamma interferon | |
dc.subject | immunoglobulin enhancer binding protein | |
dc.subject | transcription factor | |
dc.subject | allele | |
dc.subject | article | |
dc.subject | binding affinity | |
dc.subject | binding site | |
dc.subject | case control study | |
dc.subject | controlled study | |
dc.subject | disease course | |
dc.subject | DNA polymorphism | |
dc.subject | family study | |
dc.subject | gene expression | |
dc.subject | genetic analysis | |
dc.subject | genetic association | |
dc.subject | genetic susceptibility | |
dc.subject | genetic variability | |
dc.subject | human | |
dc.subject | infection sensitivity | |
dc.subject | major clinical study | |
dc.subject | population research | |
dc.subject | priority journal | |
dc.subject | South Africa | |
dc.subject | tuberculosis | |
dc.subject | Alleles | |
dc.subject | Case-Control Studies | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Humans | |
dc.subject | Interferon-alpha | |
dc.subject | NF-kappa B | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | South Africa | |
dc.subject | Tuberculosis | |
dc.title | Association between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene | |
dc.type | Article |