Evidence for the binding of the carcinogen 3 methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid

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dc.contributor.authorJones P.A.
dc.contributor.authorGevers W.
dc.contributor.authorHawtrey A.O.
dc.date.accessioned2011-05-15T16:03:25Z
dc.date.available2011-05-15T16:03:25Z
dc.date.issued1973
dc.description.abstractThe binding of [3H]3 methylcholanthrene to the DNA of hamster fibroblasts was studied by using chemical methods for DNA degradation. DNA depurinated by mild acid hydrolysis released approximately 1/2 of the radioactivity at the same rate as the purine bases, but the resulting apurinic acid still contained radioactive carcinogen.
dc.description.versionArticle
dc.identifier.citationBiochemical Journal
dc.identifier.citation135
dc.identifier.citation2
dc.identifier.issn2646021
dc.identifier.urihttp://hdl.handle.net/10019.1/12614
dc.subject3 methylcholanthrene
dc.subjectdna
dc.subjectpurine
dc.subjectpyrimidine
dc.subjectcolumn chromatography
dc.subjectdrug analysis
dc.subjectdrug binding
dc.subjectfibroblast
dc.subjectin vitro study
dc.subjectmethylcholanthrene h 3
dc.subjectpharmacology
dc.subjecttheoretical study
dc.subjectAnimal
dc.subjectBinding Sites
dc.subjectChromatography
dc.subjectDNA
dc.subjectFibroblasts
dc.subjectHamsters
dc.subjectHydrolysis
dc.subjectMethylcholanthrene
dc.subjectPurine Nucleotides
dc.subjectPyrimidine Nucleotides
dc.subjectTissue Culture
dc.subjectTritium
dc.titleEvidence for the binding of the carcinogen 3 methylcholanthrene to both the purine and the pyrimidine bases of hamster fibroblast deoxyribonucleic acid
dc.typeArticle
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