Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder

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dc.contributor.authorStein D.J.
dc.contributor.authorMontgomery S.A.
dc.contributor.authorKasper S.
dc.contributor.authorTanghoj P.
dc.date.accessioned2011-05-15T15:59:18Z
dc.date.available2011-05-15T15:59:18Z
dc.date.issued2001
dc.description.abstractAlthough serotonin reuptake inhibitors (SRIs) are the medications of choice in the treatment of obsessive-compulsive disorder (OCD), only 50-60% of patients respond to a single trial of any of these agents. Improved knowledge of the predictors of response to treatment may have important clinical implications. Data from a large randomized placebo-controlled trial of citalopram in OCD was analysed using logistic regression to determine predictors of response. Demographic (age, sex), clinical (OCD severity and duration, depression severity, prior treatment) and trial variables (citalopram dose, treatment duration) were included. Subjects with longer duration of OCD, more severe OCD symptoms or previous selective SRI use were less likely to be responders in the citalopram trial. In contrast, subjects who received adequate medication doses for sufficient periods of time in the citalopram trial were more likely to be responders. Despite greater awareness of OCD in recent years, there is evidence that the disorder continues to be underdiagnosed and undertreated. The data here emphasize the crucial importance of early diagnosis and treatment of OCD, and of pharmacotherapy with appropriate dose and duration. © 2001 Lippincott Williams & Wilkins.
dc.description.versionArticle
dc.identifier.citationInternational Clinical Psychopharmacology
dc.identifier.citation16
dc.identifier.citation6
dc.identifier.issn2681315
dc.identifier.urihttp://hdl.handle.net/10019.1/11103
dc.subjectcitalopram
dc.subjectserotonin uptake inhibitor
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdisease course
dc.subjectdisease severity
dc.subjectdose response
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjectearly diagnosis
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobsession
dc.subjectprediction
dc.subjectpriority journal
dc.subjectregression analysis
dc.subjecttreatment planning
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectCitalopram
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObsessive-Compulsive Disorder
dc.subjectOdds Ratio
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectPsychiatric Status Rating Scales
dc.subjectRegression Analysis
dc.subjectSerotonin Uptake Inhibitors
dc.titlePredictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder
dc.typeArticle
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