Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital

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dc.contributor.authorChabikuli N.O.
dc.contributor.authorDatonye D.O.
dc.contributor.authorNachega J.
dc.contributor.authorAnsong D.
dc.date.accessioned2011-10-13T16:58:15Z
dc.date.available2011-10-13T16:58:15Z
dc.date.issued2010
dc.description.abstractBackground: Adherence to antiretroviral therapy (ART) is a strong predictor of progression to AIDS and death. It remains the most important potentially alterable factor that determines treatment outcomes. Methods: The study is a cross-sectional survey of self-reported adherence to ART and associated factors. It included a randomly selected sample of 100 adult patients who began ART between June 2006 and December 2007. A modified Adult AIDS Clinical Trials Group questionnaire was used. The analysis compared self-reported adherence levels by factor and viral load test results. Results: Only 71% of patients had an adherence > 95%. Poor adherence was related to changes in daily routines (being away from home [21%] and busy with other things [17%]). All patients with symptoms suggestive of clinical depression had virologic failure. More unemployed patients (50.7%) had virologic failure than did employed patients (40%) (p = < 0.05). The clinic had a tenfold increase in patient enrolment and a ninefold decline in staff-to-patient ratio, and the proportion of patients lost to follow-up doubled in the preceding four years. Conclusion: Adherence to ART was poor. The capacity of the clinic to manage patients adequately has declined significantly. Decentralisation of ART services to primary health care facilities should be considered. © SAAFP.
dc.description.versionArticle
dc.identifier.citationSouth African Family Practice
dc.identifier.citation52
dc.identifier.citation4
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79960342380&partnerID=40&md5=9841eb0ad8db7b5e8a270b98c7cdf683
dc.identifier.issn1726426X
dc.identifier.urihttp://hdl.handle.net/10019.1/16659
dc.subjectAdherence
dc.subjectART
dc.subjectHIV
dc.subjectHuman resource
dc.subjectSouth Africa
dc.titleAdherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital
dc.typeArticle
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