An open trial of citalopram in adolescents with post-traumatic stress disorder

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dc.contributor.authorSeedat S.
dc.contributor.authorLockhat R.
dc.contributor.authorKaminer D.
dc.contributor.authorZungu-Dirwayi N.
dc.contributor.authorStein D.J.
dc.date.accessioned2011-05-15T15:59:18Z
dc.date.available2011-05-15T15:59:18Z
dc.date.issued2001
dc.description.abstractIn this preliminary, 12-week open-label study, eight adolescents with moderate to severe post-traumatic stress disorder (PTSD) were treated with citalopram the most selective of the selective serotonin reuptake inhibitors) in a fixed daily dose of 20 mg, and rated at 2-week intervals. The Clinician-Administered PTSD Scale (Child and Adolescent Version) was the primary measure used to assess treatment outcome. Core PTSD symptoms (re-experiencing, avoidance, and hyperarousal symptoms) showed statistically significant improvement at week 12 on the Clinician-Administered PTSD Scale (Child and Adolescent Version) (CAPS-CA), with a 38% reduction in total CAPS scores between baseline and endpoint. Citalopram failed to effect improvement on self-reported depressive symptoms. All seven adolescent completers were rated as much improved or very much improved on Clinical Global impression improvement scores. Citalopram was well-tolerated overall with reported adverse experiences being relatively benign. However, larger, controlled trials are needed to consolidate these preliminary, results. © 2001 Lippincott Williams & Wilkins.
dc.description.versionArticle
dc.identifier.citationInternational Clinical Psychopharmacology
dc.identifier.citation16
dc.identifier.citation1
dc.identifier.issn2681315
dc.identifier.urihttp://hdl.handle.net/10019.1/11105
dc.subjectcitalopram
dc.subjectserotonin uptake inhibitor
dc.subjectadolescent
dc.subjectarticle
dc.subjectavoidance behavior
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectdepression
dc.subjectdose response
dc.subjectdrug tolerability
dc.subjectepistaxis
dc.subjecthuman
dc.subjectposttraumatic stress disorder
dc.subjectpriority journal
dc.subjectscoring system
dc.subjectself report
dc.subjecttreatment outcome
dc.subjectAdolescent
dc.subjectArousal
dc.subjectCitalopram
dc.subjectCombined Modality Therapy
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPersonality Assessment
dc.subjectPsychotherapy
dc.subjectStress Disorders, Post-Traumatic
dc.subjectTreatment Outcome
dc.titleAn open trial of citalopram in adolescents with post-traumatic stress disorder
dc.typeArticle
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