Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
BMC (part of Springer Nature)
Abstract
Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter
parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development of myocardial
infarction in these patients. At present, there are limited therapies aimed at specifically protecting the diabetic heart
at risk from hyperglycemia-induced injury. Oxidative stress, through over production of free radical species, has been
hypothesized to alter mitochondrial function and abnormally augment the activity of the NADPH oxidase enzyme
system resulting in accelerated myocardial injury within a diabetic state. This has led to a dramatic increase in the
exploration of plant-derived materials known to possess antioxidative properties. Several edible plants contain various
natural constituents, including polyphenols that may counteract oxidative-induced tissue damage through their
modulatory effects of intracellular signaling pathways. Rooibos, an indigenous South African plant, well-known for its
use as herbal tea, is increasingly studied for its metabolic benefits. Prospective studies linking diet rich in polyphenols
from rooibos to reduced diabetes associated cardiovascular complications have not been extensively assessed.
Aspalathin, a flavonoid, and phenylpyruvic acid-2-O-β-D-glucoside, a phenolic precursor, are some of the major
compounds found in rooibos that can ameliorate hyperglycemia-induced cardiomyocyte damage in vitro. While the
latter has demonstrated potential to protect against cell apoptosis, the proposed mechanism of action of aspalathin is
linked to its capacity to enhance the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression, an
intracellular antioxidant response element. Thus, here we review literature on the potential cardioprotective properties
of flavonoids and a phenylpropenoic acid found in rooibos against diabetes-induced oxidative injury.
Description
CITATION: Dludla, P., et al. 2017. Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutrition & Metabolism, 14:45, doi:10.1186/s12986-017-0200-8.
The original publication is available at https://nutritionandmetabolism.biomedcentral.com
The original publication is available at https://nutritionandmetabolism.biomedcentral.com
Keywords
Diabetes, Hyperglycemia, Oxidative stress, Heart--Hypertrophy, Polyphenols, Rooibos tea
Citation
Dludla, P., et al. 2017. Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutrition & Metabolism, 14:45, doi:10.1186/s12986-017-0200-8