Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent

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dc.contributor.authorUys P.W.
dc.contributor.authorWarren R.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorMurray M.
dc.contributor.authorVictor T.C.
dc.date.accessioned2011-05-15T15:56:54Z
dc.date.available2011-05-15T15:56:54Z
dc.date.issued2009
dc.description.abstractThe long-term persistence of Mycobacterium tuberculosis in communities with high tuberculosis prevalence is a serious problem aggravated by the presence of drug-resistant tuberculosis strains. Drug resistance in an individual patient is often discovered only after a long delay, particularly if the diagnosis is based on current culture-based drug sensitivity testing methods. During such delays, the patient may transmit tuberculosis to his or her contacts. Rapid diagnosis of drug resistance would be expected to reduce this transmission and hence to decrease the prevalence of drug-resistant strains. To investigate this quantitatively, a mathematical model was constructed, assuming a homogeneous population structure typical of communities in South Africa where tuberculosis incidence is high. Computer simulations performed with this model showed that current control strategies will not halt the spread of multidrug-resistant tuberculosis in such communities. The simulations showed that the rapid diagnosis of drug resistance can be expected to reduce the incidence of drug-resistant cases provided the additional measure of screening within the community is implemented. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Microbiology
dc.identifier.citation47
dc.identifier.citation5
dc.identifier.issn951137
dc.identifier.other10.1128/JCM.02289-08
dc.identifier.urihttp://hdl.handle.net/10019.1/10106
dc.subjectarticle
dc.subjectcomputer assisted diagnosis
dc.subjectcomputer simulation
dc.subjectcontrolled study
dc.subjectdrug sensitivity
dc.subjectepidemiological data
dc.subjectincidence
dc.subjectinfection control
dc.subjectmathematical model
dc.subjectmultidrug resistant tuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectpopulation structure
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectSouth Africa
dc.subjectComputer Simulation
dc.subjectDrug Resistance, Multiple, Bacterial
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectModels, Theoretical
dc.subjectMycobacterium tuberculosis
dc.subjectSouth Africa
dc.subjectTime Factors
dc.subjectTuberculosis, Multidrug-Resistant
dc.subjectMycobacterium tuberculosis
dc.titlePotential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent
dc.typeArticle
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