Falsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurements

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dc.contributor.authorHamer, Henrike M.en_ZA
dc.contributor.authorFinken, Martijn J. J.en_ZA
dc.contributor.authorVan Herwaarden, Antonius E.en_ZA
dc.contributor.authorDu Toit, Therinaen_ZA
dc.contributor.authorSwart, Amanda C.en_ZA
dc.contributor.authorHeijboer, Annemieke C.en_ZA
dc.date.accessioned2019-10-24T09:24:45Z
dc.date.available2019-10-24T09:24:45Z
dc.date.issued2018-01
dc.descriptionCITATION: Hamer, H.M. et al. 2018. Falsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurements. Clinical Chemistry and Laboratory Medicine (CCLM), 56(6):e141–e143, doi:10.1515/cclm-2017-1028.en_ZA
dc.descriptionThe original publication is available at https://www.degruyter.com/view/j/cclmen_ZA
dc.description.abstractIn newborns with atypical genitalia, suspicious for a disorder of sex development (DSD), measurement of testosterone is an essential part in the diagnostic workup. Previously, direct testosterone immunoassays have proven to be inaccurate because they tend to overestimate testosterone concentrations in the lower ranges, such as those in females and infants, but specifically also in neonates. Based on the concern for cross-reactivity in neonatal samples, the recently revised UK guideline on the initial evaluation of DSD from the UK Society for Endocrinology recommends that steroids in plasma or serum are measured by either LC-MS/MS or immunoassays after organic solvent extraction. The use of LC-MS/MS was considered superior by a recent consensus meeting of DSD experts across Europe, although validation and quality control remain challenging.en_ZA
dc.description.versionPublishers versionen_ZA
dc.identifier.citationHamer, H.M. et al. 2018. Falsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurements. Clinical Chemistry and Laboratory Medicine (CCLM), 56(6):e141–e143, doi:10.1515/cclm-2017-1028.en_ZA
dc.identifier.issn1437-4331 (online)
dc.identifier.issn1434-6621 (print)
dc.identifier.otherdoi:10.1515/cclm-2017-1028
dc.identifier.urihttp://hdl.handle.net/10019.1/106715
dc.language.isoen_ZAen_ZA
dc.publisherDe Gruyteren_ZA
dc.rights.holderDe Gruyteren_ZA
dc.subjectPlasma testosterone, Testosterone;en_ZA
dc.subjectTestosteroneen_ZA
dc.subjectTestosterone immunoassaysen_ZA
dc.subjectDisorder of sex development -- DSDen_ZA
dc.subjectImmunoassaysen_ZA
dc.subjectNeonateen_ZA
dc.titleFalsely elevated plasma testosterone concentrations in neonates : importance of LC-MS/ MS measurementsen_ZA
dc.typeArticleen_ZA
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