Cardiovascular genetic assessment and treatment in middle age to reduce the risk of heart disease and dementia in old age
dc.contributor.author | Kotze M.J. | |
dc.contributor.author | Thiart R. | |
dc.contributor.author | Hugo F.J. | |
dc.contributor.author | Potocnik F.C.W. | |
dc.date.accessioned | 2011-05-15T15:54:36Z | |
dc.date.available | 2011-05-15T15:54:36Z | |
dc.date.issued | 2006 | |
dc.description.abstract | Assessment and treatment of cardiovascular disease (CVD) risk factors as a preventable cause of cognitive decline, morbidity and mortality is an important clinical goal. The apolipoprotein E (Apo E) gene provides a genetic link between CVD and the development of Alzheimer's disease (AD). The E4 allele increases the risk of coronary heart disease by more than 40% and contributes to the development of late-onset AD in more than 50% of affected patients. Disease expression in the presence of this allele is triggered by interaction with modifiable risk factors such as smoking, alcohol intake and high-calorie diets. It also displays differential therapeutic responses with use of cholesterol-lowering statins and acetylcholinesterase inhibitors. Apo E genotyping as part of a comprehensive evaluation of multiple CVD risk factors, performed in conjunction with nutrition and cognitive assessments, provides the opportunity to optimise treatment to the needs of the individual. | |
dc.description.version | Review | |
dc.identifier.citation | South African Family Practice | |
dc.identifier.citation | 48 | |
dc.identifier.citation | 4 | |
dc.identifier.issn | 1726426X | |
dc.identifier.uri | http://hdl.handle.net/10019.1/9292 | |
dc.title | Cardiovascular genetic assessment and treatment in middle age to reduce the risk of heart disease and dementia in old age | |
dc.type | Review |