Phylogenomics of the genus Mus (Rodentia; Muridae): Extensive genome repatterning is not restricted to the house mouse

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dc.contributor.authorVeyrunes F.
dc.contributor.authorDobigny G.
dc.contributor.authorYang F.
dc.contributor.authorO'Brien P.C.M.
dc.contributor.authorCatalan J.
dc.contributor.authorRobinson T.J.
dc.contributor.authorBritton-Davidian J.
dc.date.accessioned2011-05-15T16:00:24Z
dc.date.available2011-05-15T16:00:24Z
dc.date.issued2006
dc.description.abstractThe house mouse (Mus musculus) is universally adopted as the mammalian laboratory model, and it is involved in most studies of large-scale comparative genomics. Paradoxically, this taxon is rarely the index species for evolutionary analyses of genome architecture owing to its highly rearranged karyotype. To unravel the origin and nature of this extensive repatterning genome, we performed a multidirectional chromosome painting study of representative species within the genus Mus. However, the latter includes four extant subgenera (Mus, Coelomys, Nannomys and Pyromys) between which the phylogenetic relationships remain elusive despite the numerous molecular studies. Comparative genomic maps were established using chromosome-specific painting probes of the laboratory mouse and Nannomys minutoides. Hence, by integrating closely related species within Mus, this study allowed us to: (i) unambiguously resolve for the first time the long-standing controversial phylogeny, (ii) trace the evolution of genome organization in the house mouse, (iii) track rearrangements that necessitated new centromere locations, i.e. formation of neocentromere or reactivation of latent centromeres, (iv) reveal an extremely high rate of karyotypic evolution, with a 10- to 30-fold acceleration which was coincidental with subgeneric cladogenesis and (v) highlight genomic areas of interest for high-resolution studies on neocentromere formation and synteny breakpoints. © 2006 The Royal Society.
dc.description.versionArticle
dc.identifier.citationProceedings of the Royal Society B: Biological Sciences
dc.identifier.citation273
dc.identifier.citation1604
dc.identifier.issn9628452
dc.identifier.other10.1098/rspb.2006.3670
dc.identifier.urihttp://hdl.handle.net/10019.1/11684
dc.subjectevolution
dc.subjectgenomics
dc.subjectphylogenetics
dc.subjectphylogeny
dc.subjectrodent
dc.subjectanimal cell
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcentromere
dc.subjectchromosome painting
dc.subjectcontrolled study
dc.subjectexperimental mouse
dc.subjectfemale
dc.subjectfluorescence in situ hybridization
dc.subjectgene mapping
dc.subjectgenome analysis
dc.subjectgenomics
dc.subjectkaryotype
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphylogeny
dc.subjectpriority journal
dc.subjectAnimals
dc.subjectEvolution, Molecular
dc.subjectFemale
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectKaryotyping
dc.subjectMale
dc.subjectMice
dc.subjectMuridae
dc.subjectPhylogeny
dc.subjectRats
dc.subjectSpecies Specificity
dc.subjectMammalia
dc.subjectMuridae
dc.subjectMus
dc.subjectMus musculus
dc.subjectRodentia
dc.titlePhylogenomics of the genus Mus (Rodentia; Muridae): Extensive genome repatterning is not restricted to the house mouse
dc.typeArticle
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