Identification of env subtypes in fourteen HIV type 1 isolates from South Africa

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dc.contributor.authorEngelbrecht S.
dc.contributor.authorLaten J.D.
dc.contributor.authorSmith T.-L.
dc.contributor.authorVan Rensburg E.J.
dc.date.accessioned2011-05-15T16:03:23Z
dc.date.available2011-05-15T16:03:23Z
dc.date.issued1995
dc.description.abstractAll subtypes of HIV-1 have been identified in Africa. The envelope glycoprotein of the HIV-1 is the most variable region of the virus, with the third variable region, including the V3 loop, a major target of vaccine research. This paper reports the identification of the HIV-1 subtypes present in 14 viral strains, isolated between 1984 and 1992 in South Africa. HIV-1 strains were isolated routinely at Tygerberg Hospital in the Western Cape region, with genomic DNA isolated from virus-infected cultures. After presenting the distance calculations and describing the tree constructions and bootstrap analysis, the authors emphasize the need for ongoing molecular epidemiological analysis of HIV-1 subtypes to track the current epidemic in South Africa. More rapid methods will facilitate subtyping to monitor the circulation and spread of HIV-1 subpopulations in the country.
dc.description.versionNote
dc.identifier.citationAIDS Research and Human Retroviruses
dc.identifier.citation11
dc.identifier.citation10
dc.identifier.issn8892229
dc.identifier.urihttp://hdl.handle.net/10019.1/12597
dc.subjectvirus envelope protein
dc.subjectacquired immune deficiency syndrome
dc.subjectadult
dc.subjectclinical article
dc.subjectgenetic conservation
dc.subjecthuman
dc.subjecthuman immunodeficiency virus 1
dc.subjecthuman immunodeficiency virus infection
dc.subjectmale
dc.subjectnote
dc.subjectnucleotide sequence
dc.subjectpolymerase chain reaction
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectvirus characterization
dc.subjectvirus genome
dc.subjectAfrica
dc.subjectAfrica South Of The Sahara
dc.subjectBiology
dc.subjectDeveloping Countries
dc.subjectDiseases
dc.subjectEnglish Speaking Africa
dc.subjectGenetics
dc.subjectHiv
dc.subjectHiv Infections
dc.subjectResearch Report
dc.subjectSouth Africa
dc.subjectSouthern Africa
dc.subjectViral Diseases
dc.subjectAdult
dc.subjectAmino Acid Sequence
dc.subjectGene Products, env
dc.subjectHIV Envelope Protein gp120
dc.subjectHIV-1
dc.subjectHuman
dc.subjectMolecular Sequence Data
dc.subjectPeptide Fragments
dc.subjectPhylogeny
dc.subjectSequence Homology, Amino Acid
dc.subjectSouth Africa
dc.subjectSupport, Non-U.S. Gov't
dc.titleIdentification of env subtypes in fourteen HIV type 1 isolates from South Africa
dc.typeNote
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