Release of Enterococcus mundtii Bacteriocin ST4SA from Self-Setting Brushite Bone Cement

Simple item page
dc.contributor.authorvan Staden A.D.
dc.contributor.authorHeunis T.D.J.
dc.contributor.authorDicks L.M.T.
dc.date.accessioned2011-10-13T16:59:21Z
dc.date.available2011-10-13T16:59:21Z
dc.date.issued2011
dc.description.abstractMaxillofacial and craniofacial surgery is on the increase, which exposes more patients at risk of acquiring microbial infections. The use of antibiotic-loaded calcium phosphate bone cements has been shown to reduce the incidence of infection. A marked increase in antibiotic-resistant pathogens, including multidrug-resistant pathogens, has been reported. This has led to the investigation of various compounds as alternatives to conventional treatments. In this paper, we report on the incorporation and release of a broad-spectrum class II antimicrobial peptide, bacteriocin ST4SA produced by Enterococcus mundtii, into a calcium orthophosphate-based bone cement. Our results suggest class II bacteriocins may be incorporated into self-setting bone cements to produce implants with antimicrobial activity over extended periods of time. © 2011 Springer Science + Business Media, LLC.
dc.description.versionArticle
dc.identifier.citationProbiotics and Antimicrobial Proteins
dc.identifier.citation3
dc.identifier.citation2
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79958779824&partnerID=40&md5=edf7eb60dab5e56d4888603605c8a1c8
dc.identifier.issn18671306
dc.identifier.other10.1007/s12602-011-9074-7
dc.identifier.urihttp://hdl.handle.net/10019.1/17078
dc.titleRelease of Enterococcus mundtii Bacteriocin ST4SA from Self-Setting Brushite Bone Cement
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications