Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram

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dc.contributor.authorCassimjee N.
dc.contributor.authorFouche J.-P.
dc.contributor.authorBurnett M.
dc.contributor.authorLochner C.
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorDupont P.
dc.contributor.authorStein D.J.
dc.contributor.authorCloete K.J.
dc.contributor.authorCarey P.D.
dc.date.accessioned2011-05-15T15:59:57Z
dc.date.available2011-05-15T15:59:57Z
dc.date.issued2010
dc.description.abstractIt has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety disorder completed magnetic resonance imaging both before and after 12-weeks of treatment with 20 mg/day escitalopram. No increases in structural grey matter were found, but there were decreases in bilateral superior temporal cortex, vermis and the left cerebellum volumes following 12 weeks of treatment with escitalopram. These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific. © 2010 Springer Science+Business Media, LLC..
dc.description.versionArticle
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation25
dc.identifier.citation4
dc.identifier.issn8857490
dc.identifier.other10.1007/s11011-010-9218-6
dc.identifier.urihttp://hdl.handle.net/10019.1/11450
dc.subjectescitalopram
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbrain size
dc.subjectcerebellum vermis
dc.subjectclinical article
dc.subjectfemale
dc.subjectgray matter
dc.subjecthuman
dc.subjectmale
dc.subjectnuclear magnetic resonance imaging
dc.subjectsocial phobia
dc.subjecttemporal cortex
dc.subjecttreatment outcome
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnxiety
dc.subjectAnxiety Disorders
dc.subjectBrain
dc.subjectCitalopram
dc.subjectDepressive Disorder
dc.subjectDiagnostic and Statistical Manual of Mental Disorders
dc.subjectFemale
dc.subjectFrontal Lobe
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPatient Compliance
dc.subjectPsychiatric Status Rating Scales
dc.subjectSerotonin Uptake Inhibitors
dc.subjectTemporal Lobe
dc.subjectYoung Adult
dc.titleChanges in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
dc.typeArticle
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