Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria

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dc.contributor.authorvan Zyl, Winschau F.en_ZA
dc.contributor.authorDeane, Shelly M.en_ZA
dc.contributor.authorDicks, Leon M. T.en_ZA
dc.date.accessioned2022-08-18T07:08:00Zen_ZA
dc.date.available2022-08-18T07:08:00Zen_ZA
dc.date.issued2020-10en_ZA
dc.descriptionCITATION: van Zyl, W. F.; Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1). doi:10.1080/19490976.2020.1831339en_ZA
dc.descriptionThe original publication is available at https://www.tandfonline.com/loi/kgmi20en_ZA
dc.description.abstractGastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host’s GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed.en_ZA
dc.description.urihttps://www.tandfonline.com/doi/full/10.1080/19490976.2020.1831339en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent25 pagesen_ZA
dc.identifier.citationvan Zyl, W. F.; Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1). doi:10.1080/19490976.2020.1831339en_ZA
dc.identifier.issn1949-0984 (online)en_ZA
dc.identifier.issn1949-0976 (print)en_ZA
dc.identifier.otherdoi:10.1080/19490976.2020.1831339en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125616en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherTaylor & Francisen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectGastrointestinal system -- Microbiologyen_ZA
dc.subjectLactic acid bacteriaen_ZA
dc.subjectProbioticsen_ZA
dc.subjectGastrointestinal tracten_ZA
dc.subjectIntestines -- Infectionsen_ZA
dc.subjectAnti-infective agentsen_ZA
dc.subjectAntimicrobial compoundsen_ZA
dc.subjectBacteriocinsen_ZA
dc.titleMolecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteriaen_ZA
dc.typeArticleen_ZA
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