Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria
Date
2020-10
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a major cause of morbidity and mortality worldwide. Treatment is becoming increasingly difficult due to the increase in number of species that have developed resistance to antibiotics. Probiotic lactic acid bacteria (LAB) have considerable potential as alternatives to antibiotics, both in prophylactic and therapeutic applications. Several studies have documented a reduction, or prevention, of GI diseases by probiotic bacteria. Since the activities of probiotic bacteria are closely linked with conditions in the host’s GI-tract (GIT) and changes in the population of enteric microorganisms, a deeper understanding of gut-microbial interactions is required in the selection of the most suitable probiotic. This necessitates a deeper understanding of the molecular capabilities of probiotic bacteria. In this review, we explore how probiotic microorganisms interact with enteric pathogens in the GIT. The significance of probiotic colonization and persistence in the GIT is also addressed.
Description
CITATION: van Zyl, W. F.; Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1). doi:10.1080/19490976.2020.1831339
The original publication is available at https://www.tandfonline.com/loi/kgmi20
The original publication is available at https://www.tandfonline.com/loi/kgmi20
Keywords
Gastrointestinal system -- Microbiology, Lactic acid bacteria, Probiotics, Gastrointestinal tract, Intestines -- Infections, Anti-infective agents, Antimicrobial compounds, Bacteriocins
Citation
van Zyl, W. F.; Deane, S. M. & Dicks, L. M. T. 2020. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes, 12(1). doi:10.1080/19490976.2020.1831339