Depression, alcohol use and adherence to antiretroviral therapy in Sub-Saharan Africa : a systematic review

Simple item page
dc.contributor.authorNakimuli-Mpungu E.
dc.contributor.authorBass J.K.
dc.contributor.authorAlexandre P.
dc.contributor.authorMills E.J.
dc.contributor.authorMusisi S.
dc.contributor.authorRam M.
dc.contributor.authorKatabira E.
dc.contributor.authorNachega J.B.
dc.date.accessioned2012-02-22T09:27:08Z
dc.date.available2012-02-22T09:27:08Z
dc.date.issued2011
dc.description.abstractThis study evaluated estimates of depression symptoms, major depression, alcohol use or disorders and their association with ART adherence in sub-Saharan Africa. Studies published between January 1, 2006 and July 31, 2011 that documented rates of these mental health problems were identified through electronic databases. A pooled analysis of 23 studies reporting rates of depression symptoms and six studies reporting rates of major depression indicated a pooled estimate of 31.2% (95% CI 25.5-38.2%, Tau 2 = 0.23) and 18% (95% CI 12.3-25.8%, Tau 2 = 0.19) respectively. Few studies reported rates of alcohol use or disorders, and so we did not pool their estimates. Likelihood of achieving good adherence was 55% lower among those with depression symptoms compared to those without (pooled OR = 0.45 (95% CI 0.31-0.66, Tau 2 = 0.20, P value = 0.000). Interventions to improve mental health of HIV-positive individuals and to support adherence are desperately needed in sub-Saharan Africa. © 2011 Springer Science+Business Media, LLC.
dc.identifier.citationAIDS and Behavior
dc.identifier.citation1
dc.identifier.citation18
dc.identifier.issn10907165
dc.identifier.otherdoi:10.1007/s10461-011-0087-8
dc.identifier.urihttp://hdl.handle.net/10019.1/19850
dc.titleDepression, alcohol use and adherence to antiretroviral therapy in Sub-Saharan Africa : a systematic review
dc.typeArticle in Press
Files
Collections
Stellenbosch University - Scopus Publications