A comparison of 4-week peptic ulcer healing rates following treatment with antacids and ranitidine
Date
1984-06
Authors
Bezuidenhout, D. J. J.
Perold, J. G.
Adams, G.
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group (HMPG)
Abstract
Eighty-eight patients with endoscopically proven gastric and duodenal ulceration were treated with ranitidine (Zantac; Glaxo) or an antacid preparation containing aluminium hydroxide and magnesium trisilicate (Gelusil; Warner) over a 4-week period to assess healing. Clinical, haematological and biochemical assessment and endoscopy were performed at the beginning and at the end of this period. Of the duodenal ulcers, 74% healed on ranitidine therapy and 63% on Gelusil. This difference was not statistically significant (χ2(1) = 0,55). Of the gastric ulcers 58% healed on ranitidine therapy and 35% on Gelusil, but this difference did not reach statistical significance (χ2(1) = 1,79). There was no significant difference between the two therapies with regard to symptomatic relief in the duodenal ulcer group, but ranitidine produced significantly better results in the gastric ulcer group. No side-effects were noted in either group.
Description
The original publication is available at http://www.samj.org.za
Keywords
Peptic ulcer -- Treatment, Antacids, Ranitidine
Citation
Bezuidenhout, D. J. J., Perold, J. G. & Adams, G. 1984. A comparison of 4-week peptic ulcer healing rates following treatment with antacids and ranitidine. South African Medical Journal, 65(1007-1009).