Intervention for alcohol use disorders at an HIV care clinic in Harare : a pilot and feasibility study

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dc.contributor.authorMadhombiro, Munyaradzien_ZA
dc.contributor.authorDube, Bazondlileen_ZA
dc.contributor.authorDube, Michelleen_ZA
dc.contributor.authorZunza, Moleenen_ZA
dc.contributor.authorChibanda, Dixonen_ZA
dc.contributor.authorRusakaniko, Simbarasheen_ZA
dc.contributor.authorSeedat, Soraya, 1966-en_ZA
dc.date.accessioned2021-11-17T07:27:52Z
dc.date.available2021-11-17T07:27:52Z
dc.date.issued2019
dc.descriptionCITATION: Madhombiro, M., et al. 2019. Intervention for alcohol use disorders at an HIV care clinic in Harare : a pilot and feasibility study. Addiction Science and Clinical Practice, 14:16, doi:10.1186/s13722-019-0143-7.
dc.descriptionThe original publication is available at https://ascpjournal.biomedcentral.com
dc.description.abstractBackground: Alcohol use in HIV infected patients is associated with risky sexual behaviour, poor adherence to Highly Active Antiretroviral Therapy, treatment failure and increased physiologic harm. The objectives of the study were to pilot the outcome assessments to be used in the trial proper, assess the feasibility of delivery of a brief MI/CBT intervention compared to an WHO mhGAP intervention for problematic alcohol use in PLWH in Zimbabwe, and pilot the effectiveness (on alcohol use, functionality and CD4 count) of these interventions at 3 months in a randomised controlled trial design. Methods: An intervention for HIV infected patients with problematic alcohol use, developed through adaptation of existing evidence based psychological treatments, was assessed for its feasibility at a tertiary HIV care clinic in Zimbabwe. Registered general nurses, using a manualised protocol, delivered the intervention. Forty patients were recruited and randomised to receive either an MI/CBT intervention or the WHO mhGAP Intervention Guide for AUDs (n = 20 patients per group). Results: Out of 40 participants enrolled, 31 were successfully followed up for 3 months with a loss to follow-up rate of 23%. There was a statistically significant decrease in AUDIT score over time in both groups (p < 0.001), however no statistically significant group difference with a mean difference of 0.80, standard error of 2.07 and p = 0.70. For the CD4 count, the median and interquartile ranges at baseline for MI/CBT and WHO mhGAP IG groups were 218 (274) and 484 (211.50), respectively. At follow-up, median and interquartile ranges for the CD4 count for MI/CBT and WHO mhGAP IG groups were 390 (280) and 567 (378), respectively, indicative of improvement in immunological parameters in both arms. Conclusion: The findings from this pilot study suggests that a brief MI/CBT delivered by Registered General Nurses for problematic alcohol use is feasible in this population but will require the implementation of additional measures to improve retention. However, mechanisms to improve retention need special attention.en_ZA
dc.description.urihttps://ascpjournal.biomedcentral.com/articles/10.1186/s13722-019-0143-7#citeas
dc.description.versionPublisher's version
dc.format.extent11 pages ; illustrations
dc.identifier.citationMadhombiro, M., et al. 2019. Intervention for alcohol use disorders at an HIV care clinic in Harare : a pilot and feasibility study. Addiction Science and Clinical Practice, 14:16, doi:10.1186/s13722-019-0143-7
dc.identifier.issn1940-0640 (online)
dc.identifier.otherdoi:10.1186/s13722-019-0143-7
dc.identifier.urihttp://hdl.handle.net/10019.1/123463
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectHIV-positive persons -- Alcohol use -- Harare (Zimbabwe)en_ZA
dc.subjectHIV-positive persons -- Psychological aspects -- Harare (Zimbabwe)en_ZA
dc.subjectPatient compliance -- Harare (Zimbabwe)en_ZA
dc.titleIntervention for alcohol use disorders at an HIV care clinic in Harare : a pilot and feasibility studyen_ZA
dc.typeArticleen_ZA
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