Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart
dc.contributor.author | Reid J.V.O. | |
dc.contributor.author | Lochner A. | |
dc.contributor.author | Brink A.J. | |
dc.date.accessioned | 2011-05-15T15:59:46Z | |
dc.date.available | 2011-05-15T15:59:46Z | |
dc.date.issued | 1970 | |
dc.description.abstract | The effects of a high fat, atherogenic diet was studied on the metabolism and mechanical behaviour of the isolated perfused rat heart. Palmitate and pyruvate metabolism were similar in control and fat-fed perfused hearts. Glucose uptake was lower in the fat-fed perfused heart, but the percentages of glucose converted to 14CO2 and glycogen were similar for the two groups. Explanations for the differences in glucose uptake are discussed. Fat-fed perfused hearts, with glucose as substrate, had significantly lower values for spontaneous rate, stress relaxation and tension time per minute than control hearts. With palmitate as substrate, the fat-fed perfused hearts had decreased coronary flow rates and a greater rate of tension increase on contraction. Contraction characteristics were different when hearts were perfused with glucose, compared with palmitate, in both dietary groups. © 1970. | |
dc.description.version | Article | |
dc.identifier.citation | Journal of Molecular and Cellular Cardiology | |
dc.identifier.citation | 1 | |
dc.identifier.citation | 3 | |
dc.identifier.issn | 222828 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/11352 | |
dc.subject | carbon | |
dc.subject | carbon dioxide | |
dc.subject | glucose | |
dc.subject | glycogen | |
dc.subject | lactic acid derivative | |
dc.subject | lipid | |
dc.subject | palmitic acid derivative | |
dc.subject | pyruvic acid derivative | |
dc.subject | animal | |
dc.subject | article | |
dc.subject | atherogenic diet | |
dc.subject | biomechanics | |
dc.subject | blood | |
dc.subject | coronary artery blood flow | |
dc.subject | coronary artery disease | |
dc.subject | fat intake | |
dc.subject | heart | |
dc.subject | heart muscle | |
dc.subject | male | |
dc.subject | metabolism | |
dc.subject | pathology | |
dc.subject | perfusion | |
dc.subject | physiology | |
dc.subject | rat | |
dc.subject | tissue culture | |
dc.subject | Animal | |
dc.subject | Biomechanics | |
dc.subject | Carbon Dioxide | |
dc.subject | Carbon Isotopes | |
dc.subject | Coronary Circulation | |
dc.subject | Coronary Disease | |
dc.subject | Diet, Atherogenic | |
dc.subject | Dietary Fats | |
dc.subject | Glucose | |
dc.subject | Glycogen | |
dc.subject | Heart | |
dc.subject | Lactates | |
dc.subject | Lipids | |
dc.subject | Male | |
dc.subject | Myocardium | |
dc.subject | Palmitic Acids | |
dc.subject | Perfusion | |
dc.subject | Pyruvates | |
dc.subject | Rats | |
dc.subject | Tissue Culture | |
dc.title | Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart | |
dc.type | Article |