Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile

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dc.contributor.authorVrieling, Franken_ZA
dc.contributor.authorRonacher, Katharinaen_ZA
dc.contributor.authorKleynhans, Leanieen_ZA
dc.contributor.authorVan Den Akker, Eriken_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorOttenhoff, Tom H. M.en_ZA
dc.contributor.authorJoosten, Simone A.en_ZA
dc.date.accessioned2019-09-16T13:45:34Z
dc.date.available2019-09-16T13:45:34Z
dc.date.issued2018
dc.descriptionCITATION: Vrieling, F., et al. 2018. Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32:192–200, doi:10.1016/j.ebiom.2018.05.011.
dc.descriptionThe original publication is available at https://www.sciencedirect.com
dc.description.abstractBackground: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlyingmolecular foundations are unclear. Since lipids play a central role in the development of both DM and TB, lipid metabolism may be important for TB-DM pathophysiology. Methods: A 1H NMR spectroscopy-based platform was used to determine 225 lipid and other metabolic intermediates in plasma samples of healthy controls (n=50) and patients with TB (n=50), DM(n=50) or TB-DM (n = 27). Results: TB patients presented with wasting disease, represented by decreased amino acid levels including histidine and alanine. Conversely, DM patients were dyslipidemic as evidenced by high levels of very lowdensity lipoprotein triglycerides and low high-density lipoprotein cholesterol. TB-DM patients displayed metabolic characteristics of both wasting and dyslipidemia combined with disease interaction-specific increases in phospholipid metabolites (e.g. sphingomyelins) and atherogenic remnant-like lipoprotein particles. Biomarker analysis identified the ratios of phenylalanine/histidine and esterified cholesterol/ sphingomyelin as markers for TB classification regardless of DM-status. Conclusions: TB-DM patients possess a distinctive plasma lipid profile with pro-atherogenic properties. These findings support further research on the benefits of improved blood lipid control in the treatment of TB-DM.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2352396418301683?via%3Dihub#t0010
dc.description.versionPublisher's version
dc.format.extent9 pagesen_ZA
dc.identifier.citationVrieling, F., et al. 2018. Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32:192–200, doi:10.1016/j.ebiom.2018.05.011
dc.identifier.issn2352-3964 (online)
dc.identifier.otherdoi:10.1016/j.ebiom.2018.05.011
dc.identifier.urihttp://hdl.handle.net/10019.1/106477
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectDiabetesen_ZA
dc.subjectDiabetes mellitusen_ZA
dc.subjectTuberculosisen_ZA
dc.subjectPlasma lipidsen_ZA
dc.titlePatients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profileen_ZA
dc.typeArticleen_ZA
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