Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Background: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however
the underlyingmolecular foundations are unclear. Since lipids play a central role in the development of both DM
and TB, lipid metabolism may be important for TB-DM pathophysiology.
Methods: A 1H NMR spectroscopy-based platform was used to determine 225 lipid and other metabolic intermediates
in plasma samples of healthy controls (n=50) and patients with TB (n=50), DM(n=50) or TB-DM
(n = 27).
Results: TB patients presented with wasting disease, represented by decreased amino acid levels including
histidine and alanine. Conversely, DM patients were dyslipidemic as evidenced by high levels of very lowdensity
lipoprotein triglycerides and low high-density lipoprotein cholesterol. TB-DM patients displayed
metabolic characteristics of both wasting and dyslipidemia combined with disease interaction-specific increases
in phospholipid metabolites (e.g. sphingomyelins) and atherogenic remnant-like lipoprotein particles.
Biomarker analysis identified the ratios of phenylalanine/histidine and esterified cholesterol/
sphingomyelin as markers for TB classification regardless of DM-status.
Conclusions: TB-DM patients possess a distinctive plasma lipid profile with pro-atherogenic properties.
These findings support further research on the benefits of improved blood lipid control in the treatment
of TB-DM.
Description
CITATION: Vrieling, F., et al. 2018. Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32:192–200, doi:10.1016/j.ebiom.2018.05.011.
The original publication is available at https://www.sciencedirect.com
The original publication is available at https://www.sciencedirect.com
Keywords
Diabetes, Diabetes mellitus, Tuberculosis, Plasma lipids
Citation
Vrieling, F., et al. 2018. Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile. EBioMedicine, 32:192–200, doi:10.1016/j.ebiom.2018.05.011