Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016

dc.contributor.authorJames, Spencer L.en_ZA
dc.contributor.authorTheadom, Aliceen_ZA
dc.contributor.authorEllenbogen, Richard G.en_ZA
dc.contributor.authorBannick, Marlena S.en_ZA
dc.contributor.authorMontjoy-Venning, Wcliffen_ZA
dc.contributor.authorLucchesi, Lydia R.en_ZA
dc.contributor.authorAbbasi, Nooshinen_ZA
dc.contributor.authorAbdulkader, Rizwanen_ZA
dc.contributor.authorAbraha, Haftom Niguseen_ZA
dc.contributor.authorAdsuar, Jose C.en_ZA
dc.contributor.authorAfarideh, Mohsenen_ZA
dc.contributor.authorAgrawal, Sutapaen_ZA
dc.contributor.authorAhmadi, Alirezaen_ZA
dc.contributor.authorAhmed, Muktar Beshiren_ZA
dc.contributor.authorAichour, Amani Nidhalen_ZA
dc.contributor.authorAichour, Ibtihelen_ZA
dc.contributor.authorAichour, Miloud Taki Eddineen_ZA
dc.contributor.authorAkinyemi, Rufus Olusolaen_ZA
dc.contributor.authorAkseer, Nadiaen_ZA
dc.contributor.authorAlahdab, Faresen_ZA
dc.contributor.authorAlebel, Animuten_ZA
dc.contributor.authorAlghnam, Suliman A.en_ZA
dc.contributor.authorAli, Beriwan Abdulqadiren_ZA
dc.contributor.authorAlsharif, Ubaien_ZA
dc.contributor.authorAltirkawi, Khaliden_ZA
dc.contributor.authorAndrei, Catalina Lilianaen_ZA
dc.contributor.authorAnjomshoa, Minaen_ZA
dc.contributor.authorAnsari, Hosseinen_ZA
dc.contributor.authorAnsha, Mustafa Geletoen_ZA
dc.contributor.authorAntonio, Carl Abelardo T.en_ZA
dc.contributor.authorAppiah, Seth Christopher Yawen_ZA
dc.contributor.authorAriani, Filippoen_ZA
dc.contributor.authorAsefa, Nigus Gebremedhinen_ZA
dc.contributor.authorAsgedom, Solomon Weldegebrealen_ZA
dc.contributor.authorAtique, Sulemanen_ZA
dc.contributor.authorAwasthi, Ashishen_ZA
dc.contributor.authorQuintanilla, Beatriz Paulina Ayalaen_ZA
dc.contributor.authorAyuk, Tambe B.en_ZA
dc.contributor.authorAzzopardi, Peter S.en_ZA
dc.contributor.authorBadali, Hamiden_ZA
dc.contributor.authorBadawi, Alaaen_ZA
dc.contributor.authorBalalla, Shivanthien_ZA
dc.contributor.authorBanstola, Amriten_ZA
dc.contributor.authorBarker-Collo, Suzanne Lynen_ZA
dc.contributor.authorBarnighausen, Till Winfrieden_ZA
dc.contributor.authorBedi, Neerajen_ZA
dc.contributor.authorBehzadifar, Masouden_ZA
dc.contributor.authorBehzadifar, Meysamen_ZA
dc.contributor.authorBekele, Bayu Begashawen_ZA
dc.contributor.authorBelachew, Abate Bekeleen_ZA
dc.contributor.authorBelay, Yihalem Abebeen_ZA
dc.contributor.authorBennett, Derrick A.en_ZA
dc.contributor.authorBensenor, Isabela M.en_ZA
dc.contributor.authorBerhane, Adugnawen_ZA
dc.contributor.authorBeuran, Mirceaen_ZA
dc.contributor.authorBhalla, Ashishen_ZA
dc.contributor.authorBhaumik, Soumyadeeepen_ZA
dc.contributor.authorBhutta, Zulfiqar A.en_ZA
dc.contributor.authorBiadgo, Beleteen_ZA
dc.contributor.authorBiffino, Marcoen_ZA
dc.contributor.authorBijani, Alien_ZA
dc.contributor.authorBililign, Nigusen_ZA
dc.contributor.authorBirungi, Charlesen_ZA
dc.contributor.authorBoufous, Soufianeen_ZA
dc.contributor.authorBrazinova, Alexandraen_ZA
dc.contributor.authorBrown, Allen W.en_ZA
dc.contributor.authorCar, Mateen_ZA
dc.contributor.authorCardenas, Rosarioen_ZA
dc.contributor.authorCarrero, Juan J.en_ZA
dc.contributor.authorCarvalho, Felixen_ZA
dc.contributor.authorCastaneda-Orjuela, Carlos Aen_ZA
dc.contributor.authorCatala-Lopez, Ferranen_ZA
dc.contributor.authorChaiah, Yazanen_ZA
dc.contributor.authorChamps, Ana Paulaen_ZA
dc.contributor.authorChang, Jung-Chenen_ZA
dc.contributor.authorChoi, Jee-Young J.en_ZA
dc.contributor.authorChristopher, Devasahayam J.en_ZA
dc.contributor.authorCooper, Cyrusen_ZA
dc.contributor.authorCrowe, Christopher Stephenen_ZA
dc.contributor.authorDandona, Laliten_ZA
dc.contributor.authorDandona, Rakhien_ZA
dc.contributor.authorDaryani, Ahmaden_ZA
dc.contributor.authorDavitoiu, Dragos Virgilen_ZA
dc.contributor.authorDegefa, Meaza Girmaen_ZA
dc.contributor.authorDemoz, Gebre Teklemariamen_ZA
dc.contributor.authorDeribe, Kebedeen_ZA
dc.contributor.authorDjalalinia, Shirinen_ZA
dc.contributor.authorDo, Huyen Phucen_ZA
dc.contributor.authorDoku, David Teyeen_ZA
dc.contributor.authorDrake, Thomas M.en_ZA
dc.contributor.authorDubey, Manishaen_ZA
dc.contributor.authorDubljanin, Eleonoraen_ZA
dc.contributor.authorEl-Khatib, Ziaden_ZA
dc.contributor.authorOfori-Asenso, Richarden_ZA
dc.contributor.authorEskandarieh, Shararehen_ZA
dc.contributor.authorEsteghamati, Alirezaen_ZA
dc.contributor.authorEsteghamati, Sadafen_ZA
dc.contributor.authorFaro, Andreen_ZA
dc.contributor.authorFarzadfar, Farshaden_ZA
dc.contributor.authorFarzaei, Mohammad Hoseinen_ZA
dc.contributor.authorFereshtehnejad, Seyed-Mohammaden_ZA
dc.contributor.authorFernandes, Eduardaen_ZA
dc.contributor.authorFeyissa, Garumma Toluen_ZA
dc.contributor.authorFilip, Irinaen_ZA
dc.contributor.authorFischer, Florianen_ZA
dc.contributor.authorFukumoto, Takeshien_ZA
dc.contributor.authorGanji, Morasalehen_ZA
dc.contributor.authorGankpe, Fortune Gbetohoen_ZA
dc.contributor.authorGebre, Abadi Kahsuen_ZA
dc.contributor.authorGebrehiwot, Tsegaye Teweldeen_ZA
dc.contributor.authorGezae, Kebede Embayeen_ZA
dc.contributor.authorGopalkrishna, Gururajen_ZA
dc.contributor.authorGoulart, Alessandra C.en_ZA
dc.contributor.authorHaagsma, Juanita A.en_ZA
dc.contributor.authorHaj-Mirzaian, Arvinen_ZA
dc.contributor.authorHaj-Mirzaian, Aryaen_ZA
dc.contributor.authorHamadeh, Randah R.en_ZA
dc.contributor.authorHamidi, Sameren_ZA
dc.contributor.authorHaro, Josep Mariaen_ZA
dc.contributor.authorHassankhani, Hadien_ZA
dc.contributor.authorHassen, Hamid Yimamen_ZA
dc.contributor.authorHavmoeller, Rasmusen_ZA
dc.contributor.authorHawley, Caitlinen_ZA
dc.contributor.authorHay, Simon I.en_ZA
dc.contributor.authorHegazy, Mohamed I.en_ZA
dc.contributor.authorHendrie, Deliaen_ZA
dc.contributor.authorHenok, Andualemen_ZA
dc.contributor.authorHibstu, Desalegn Tsegawen_ZA
dc.contributor.authorHoffman, Howard J.en_ZA
dc.contributor.authorHole, Michael K.en_ZA
dc.contributor.authorRad, Enayatollah Homaieen_ZA
dc.contributor.authorHosseini, Seyed Mostafaen_ZA
dc.contributor.authorHostiuc, Sorinen_ZA
dc.contributor.authorHu, Guoqingen_ZA
dc.contributor.authorHussen, Mamusha Amanen_ZA
dc.contributor.authorIlesanmi, Olayinka Stephenen_ZA
dc.contributor.authorIrvani, Seyed Naghibien_ZA
dc.contributor.authorJakovljevic, Mihajloen_ZA
dc.contributor.authorJayaraman, Sudhaen_ZA
dc.contributor.authorJha, Ravi Prakashen_ZA
dc.contributor.authorJonas, Jost B.en_ZA
dc.contributor.authorJones, Kelly M.en_ZA
dc.contributor.authorShushtari, Zahra Jorjoranen_ZA
dc.contributor.authorJozwiak, Jacek Jerzyen_ZA
dc.contributor.authorJürisson, Mikken_ZA
dc.contributor.authorKabir, Alien_ZA
dc.contributor.authorKahsay, Amahaen_ZA
dc.contributor.authorKahssay, Mollaen_ZA
dc.contributor.authorKalani, Rizwanen_ZA
dc.contributor.authorKarch, Andreen_ZA
dc.contributor.authorKasaeian, Amiren_ZA
dc.contributor.authorKassa, Getachew Mulluen_ZA
dc.contributor.authorKassa, Tesfaye Dessaleen_ZA
dc.contributor.authorKassa, Zemenu Yohannesen_ZA
dc.contributor.authorKengne, Andre Pascalen_ZA
dc.contributor.authorKhader, Yousef Salehen_ZA
dc.contributor.authorKhafaie, Morteza Abdullatifen_ZA
dc.contributor.authorKhalid, Naumanen_ZA
dc.contributor.authorKhalil, Ibrahimen_ZA
dc.contributor.authorKhan, Ejaz Ahmaden_ZA
dc.contributor.authorKhan, Muhammad Shahzeben_ZA
dc.contributor.authorKhang, Young-Hoen_ZA
dc.contributor.authorKhazaie, Habibolahen_ZA
dc.contributor.authorKhoja, Abdullah T.en_ZA
dc.contributor.authorKhubchandani, Jagdishen_ZA
dc.contributor.authorKiadaliri, Aliasghar A.en_ZA
dc.contributor.authorKim, Danielen_ZA
dc.contributor.authorKim, Young-Eunen_ZA
dc.contributor.authorKisa, Adnanen_ZA
dc.contributor.authorKoyanagi, Aien_ZA
dc.contributor.authorKrohn, Kristopher J.en_ZA
dc.contributor.authorDefo, Barthelemy Kuateen_ZA
dc.contributor.authorDefo, Barthelemy Kuateen_ZA
dc.contributor.authorBicer, Burcu Kucuken_ZA
dc.contributor.authorKumar, G. Anilen_ZA
dc.contributor.authorKumar, Manasien_ZA
dc.contributor.authorLalloo, Ratilalen_ZA
dc.contributor.authorLami, Faris Hasanen_ZA
dc.contributor.authorLansingh, Van C.en_ZA
dc.contributor.authorLaryea, Dennis Odaien_ZA
dc.contributor.authorLatifi, Armanen_ZA
dc.contributor.authorLeshargie, Cheru Tesemaen_ZA
dc.contributor.authorLevi, Miriamen_ZA
dc.contributor.authorLi, Shanshanen_ZA
dc.contributor.authorLiben, Misgan Legesseen_ZA
dc.contributor.authorLotufo, Paulo A.en_ZA
dc.contributor.authorLunevicius, Raimundasen_ZA
dc.contributor.authorMahotra, Narayan Bahaduren_ZA
dc.contributor.authorMajdan, Mareken_ZA
dc.contributor.authorMajeed, Azeemen_ZA
dc.contributor.authorMalekzadeh, Rezaen_ZA
dc.contributor.authorManda, Ana-Lauraen_ZA
dc.contributor.authorMansournia, Mohammad Alien_ZA
dc.contributor.authorMassenburg, Benjamin Ballarden_ZA
dc.contributor.authorMate, Kedar K. V.en_ZA
dc.contributor.authorMehndiratta, Man Mohanen_ZA
dc.contributor.authorMehta, Varshilen_ZA
dc.contributor.authorMeles, Hagazien_ZA
dc.contributor.authorMelese, Addisuen_ZA
dc.contributor.authorMemiah, Peter T. N.en_ZA
dc.contributor.authorMendoza, Walteren_ZA
dc.contributor.authorMengistu, Getneten_ZA
dc.contributor.authorMeretoja, Atteen_ZA
dc.contributor.authorMeretoja, Tuomo J.en_ZA
dc.contributor.authorMestrovic, Tomislaven_ZA
dc.contributor.authorMiazgowski, Tomaszen_ZA
dc.contributor.authorMiller, Ted R.en_ZA
dc.contributor.authorMini, G. K.en_ZA
dc.contributor.authorMirica, Andreeaen_ZA
dc.contributor.authorMirrakhimov, Andreeaen_ZA
dc.contributor.authorMoazen, Babaken_ZA
dc.contributor.authorMohammadi, Moslemen_ZA
dc.contributor.authorMokdad, Ali H.en_ZA
dc.contributor.authorMolokhia, Mariamen_ZA
dc.contributor.authorMonasta, Lorenzoen_ZA
dc.contributor.authorMondello, Stefaniaen_ZA
dc.contributor.authorMoosazadeh, Mahmooden_ZA
dc.contributor.authorMoradi, Ghobaden_ZA
dc.contributor.authorMoradi, Mahmoudrezaen_ZA
dc.contributor.authorMoradi-Lakeh, Maziaren_ZA
dc.contributor.authorMoradinazar, Mehdien_ZA
dc.contributor.authorMorrison, Shane Douglasen_ZA
dc.contributor.authorMoschos, Marilita M.en_ZA
dc.contributor.authorMousavi, Seyyed Meysamen_ZA
dc.contributor.authorMurthy, Srinivasen_ZA
dc.contributor.authorMusa, Kamarul Imranen_ZA
dc.contributor.authorMustafa, Ghulamen_ZA
dc.contributor.authorNaghavi, Mohsenen_ZA
dc.contributor.authorNaik, Gurudattaen_ZA
dc.contributor.authorNajafi, Fariden_ZA
dc.contributor.authorNangia, Vinayen_ZA
dc.contributor.authorNascimento, Bruno Ramosen_ZA
dc.contributor.authorNegoi, Ionuten_ZA
dc.contributor.authorNguyen, Trang Huyenen_ZA
dc.contributor.authorNichols, Emmaen_ZA
dc.contributor.authorNingrum, Dina Nur Anggrainien_ZA
dc.contributor.authorNirayo, Yirga Legesseen_ZA
dc.contributor.authorNyasulu, Peter S.en_ZA
dc.contributor.authorOfori-Asenso, Richarden_ZA
dc.contributor.authorOgbo, Felix Akpojeneen_ZA
dc.contributor.authorOh, In-Hwanen_ZA
dc.contributor.authorOkoro, Anselmen_ZA
dc.contributor.authorOlagunju, Andrew T.en_ZA
dc.contributor.authorOlagunju, Tinuke O.en_ZA
dc.contributor.authorOlivares, Pedro R.en_ZA
dc.contributor.authorOtstavnov, Stanislav S.en_ZA
dc.contributor.authorOwolabi, Mayowa Ojoen_ZA
dc.contributor.authorP A, Maheshen_ZA
dc.contributor.authorPakhale, Smitaen_ZA
dc.contributor.authorPandey, Achyut Rajen_ZA
dc.contributor.authorPesudovs, Konraden_ZA
dc.contributor.authorPinilla-Monsalve, Gabriel D.en_ZA
dc.contributor.authorPolinder, Suzanneen_ZA
dc.contributor.authorPoustchi, Hosseinen_ZA
dc.contributor.authorPrakash, Swayamen_ZA
dc.contributor.authorQorbani, Mostafaen_ZA
dc.contributor.authorRadfar, Amiren_ZA
dc.contributor.authorRafay, Anwaren_ZA
dc.contributor.authorRafiei, Alirezaen_ZA
dc.contributor.authorAfarin Rahimi-Movaghar,en_ZA
dc.contributor.authorVafa Rahimi-Movaghar,en_ZA
dc.contributor.authorMahfuzar Rahman,en_ZA
dc.contributor.authorMuhammad Aziz Rahman,en_ZA
dc.contributor.authorRajesh Kumar Rai,en_ZA
dc.contributor.authorFatemeh Rajati,en_ZA
dc.contributor.authorUsha Ram,en_ZA
dc.contributor.authorDavid Laith Rawaf,en_ZA
dc.contributor.authorSalman Rawaf,en_ZA
dc.contributor.authorRobert C Reiner,en_ZA
dc.contributor.authorCesar Reis,en_ZA
dc.contributor.authorAndre M N Renzaho,en_ZA
dc.contributor.authorSerge Resnikoff,en_ZA
dc.contributor.authorSatar Rezaei,en_ZA
dc.contributor.authorShahab Rezaeian,en_ZA
dc.contributor.authorLeonardo Roever,en_ZA
dc.contributor.authorLuca Ronfani,en_ZA
dc.contributor.authorGholamreza Roshandel,en_ZA
dc.contributor.authorNobhojit Roy,en_ZA
dc.contributor.authorGeorge Mugambage Ruhago,en_ZA
dc.contributor.authorBasema Saddik,en_ZA
dc.contributor.authorHosein Safari,en_ZA
dc.contributor.authorSaeid Safiri,en_ZA
dc.contributor.authorMohammad Ali Sahraian,en_ZA
dc.contributor.authorPayman Salamati,en_ZA
dc.contributor.authorRaphael de Freitas Saldanha,en_ZA
dc.contributor.authorAbdallah M Samy, Juan Sanabria,en_ZA
dc.contributor.authorJoão Vasco Santos,en_ZA
dc.contributor.authorMilena M M Santric Milicevic,en_ZA
dc.contributor.authorBenn Sartorius,en_ZA
dc.contributor.authorMaheswar Satpathy,en_ZA
dc.contributor.authorIone J C Schneider,en_ZA
dc.contributor.authorDavid C Schwebel,en_ZA
dc.contributor.authorSadaf G Sepanlou,en_ZA
dc.contributor.authorHosein Shabaninejad,en_ZA
dc.contributor.authorMasood A Ali Shaikh,en_ZA
dc.contributor.authorMehran Shams-Beyranvand,en_ZA
dc.contributor.authorMehdi Sharif,en_ZA
dc.contributor.authorMahdi Sharif-Alhoseini,en_ZA
dc.contributor.authorSheikh Mohammed Shariful Islam,en_ZA
dc.contributor.authorJun She,en_ZA
dc.contributor.authorAziz Sheikh,en_ZA
dc.contributor.authorJiabin Shen,en_ZA
dc.contributor.authorKevin N Sheth,en_ZA
dc.contributor.authorKenji Shibuya,en_ZA
dc.contributor.authorMekonnen Sisay Shiferaw,en_ZA
dc.contributor.authorMika Shigematsu,en_ZA
dc.contributor.authorRahman Shiri,en_ZA
dc.contributor.authorIvy Shiue,en_ZA
dc.contributor.authorHaitham Shoman,en_ZA
dc.contributor.authorSoraya Siabani,en_ZA
dc.contributor.authorTariq J Siddiqi,en_ZA
dc.contributor.authorJoão Pedro Silva,en_ZA
dc.contributor.authorDayane Gabriele Alves Silveira,en_ZA
dc.contributor.authorDhirendra Narain Sinha,en_ZA
dc.contributor.authorMari Smith,en_ZA
dc.contributor.authorAdauto Martins Soares Filho,en_ZA
dc.contributor.authorSoheila Sobhani,en_ZA
dc.contributor.authorMoslem Soofi,en_ZA
dc.contributor.authorJoan B Soriano,en_ZA
dc.contributor.authorIreneous N Soyiri,en_ZA
dc.contributor.authorDan J Stein,en_ZA
dc.contributor.authorMark A Stokes,en_ZA
dc.contributor.authorMu'awiyyah Babale Sufiyan,en_ZA
dc.contributor.authorBruno F Sunguya,en_ZA
dc.contributor.authorJacob E Sunshine,en_ZA
dc.contributor.authorBryan L Sykes,en_ZA
dc.contributor.authorCassandra E I Szoeke,en_ZA
dc.contributor.authorRafael Tabarés-Seisdedos,en_ZA
dc.contributor.authorBraden James Te Ao,en_ZA
dc.contributor.authorArash Tehrani-Banihashemi,en_ZA
dc.contributor.authorMerhawi Gebremedhin Tekle,en_ZA
dc.contributor.authorMohamad-Hani Temsah,en_ZA
dc.contributor.authorOmar Temsah,en_ZA
dc.contributor.authorRoman Topor-Madry,en_ZA
dc.contributor.authorMiguel Tortajada-Girbés,en_ZA
dc.contributor.authorBach Xuan Tran,en_ZA
dc.contributor.authorKhanh Bao Tran,en_ZA
dc.contributor.authorLorainne Tudor Car,en_ZA
dc.contributor.authorKingsley Nnanna Ukwaja,en_ZA
dc.contributor.authorIrfan Ullah,en_ZA
dc.contributor.authorMuhammad Shariq Usman,en_ZA
dc.contributor.authorOlalekan A Uthman,en_ZA
dc.contributor.authorValdez, Pascual Ren_ZA
dc.contributor.authorVasankari, Tommi Juhanien_ZA
dc.contributor.authorVenketasubramanian, Narayanaswamyen_ZA
dc.contributor.authorFrancesco S Violante,en_ZA
dc.contributor.authorFasil Shiferaw Wagnew,en_ZA
dc.contributor.authorYasir Waheed,en_ZA
dc.contributor.authorYuan-Pang Wang,en_ZA
dc.contributor.authorKidu Gidey Weldegwergs,en_ZA
dc.contributor.authorAndrea Werdecker,en_ZA
dc.contributor.authorTissa Wijeratne,en_ZA
dc.contributor.authorAndrea Sylvia Winkler,en_ZA
dc.contributor.authorGrant M A Wyper,en_ZA
dc.contributor.authorYuichiro Yano,en_ZA
dc.contributor.authorMehdi Yaseri,en_ZA
dc.contributor.authorYasin Jemal Yasin,en_ZA
dc.contributor.authorPengpeng Ye,en_ZA
dc.contributor.authorEbrahim M Yimer,en_ZA
dc.contributor.authorPaul Yip,en_ZA
dc.contributor.authorEngida Yisma,en_ZA
dc.contributor.authorNaohiro Yonemoto,en_ZA
dc.contributor.authorSeok-Jun Yoon,en_ZA
dc.contributor.authorMichael G Yost,en_ZA
dc.contributor.authorMustafa Z Younis,en_ZA
dc.contributor.authorMahmoud Yousefifard,en_ZA
dc.contributor.authorChuanhua Yu,en_ZA
dc.contributor.authorZoubida Zaidi,en_ZA
dc.contributor.authorSojib Bin Zaman,en_ZA
dc.contributor.authorMohammad Zamani,en_ZA
dc.contributor.authorZerihun Menlkalew Zenebe,en_ZA
dc.contributor.authorSanjay Zodpey,en_ZA
dc.contributor.authorValery L Feigin,en_ZA
dc.contributor.authorTheo Vos,en_ZA
dc.contributor.authorChristopher J L Murrayen_ZA
dc.date.accessioned2021-10-15T08:30:58Z
dc.date.available2021-10-15T08:30:58Z
dc.date.issued2019-11-26
dc.descriptionCITATION: James, S. L. et al. 2019. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(1):56-87. doi:10.1016/S1474-4422(18)30415-0
dc.descriptionThe original publication is available at https://www.sciencedirect.com/journal/the-lancet-neurology
dc.description.abstractBackground: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings: In 2016, there were 27·08 million (95% uncertainty interval [UI] 24·30–30·30 million) new cases of TBI and 0·93 million (0·78–1·16 million) new cases of SCI, with age-standardised incidence rates of 369 (331–412) per 100 000 population for TBI and 13 (11–16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55·50 million (53·40–57·62 million) and of SCI was 27·04 million (24·98–30·15 million). From 1990 to 2016, the age-standardised prevalence of TBI increased by 8·4% (95% UI 7·7 to 9·2), whereas that of SCI did not change significantly (−0·2% [–2·1 to 2·7]). Age-standardised incidence rates increased by 3·6% (1·8 to 5·5) for TBI, but did not change significantly for SCI (−3·6% [–7·4 to 4·0]). TBI caused 8·1 million (95% UI 6·0–10·4 million) YLDs and SCI caused 9·5 million (6·7–12·4 million) YLDs in 2016, corresponding to age-standardised rates of 111 (82–141) per 100 000 for TBI and 130 (90–170) per 100 000 for SCI. Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. Interpretation: TBI and SCI constitute a considerable portion of the global injury burden and are caused primarily by falls and road injuries. The increase in incidence of TBI over time might continue in view of increases in population density, population ageing, and increasing use of motor vehicles, motorcycles, and bicycles. The number of individuals living with SCI is expected to increase in view of population growth, which is concerning because of the specialised care that people with SCI can require. Our study was limited by data sparsity in some regions, and it will be important to invest greater resources in collection of data for TBI and SCI to improve the accuracy of future assessments.en_ZA
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1474442218304150?via%3Dihub
dc.description.versionPublisher’s version
dc.format.extent32 pages ; illustrations, maps
dc.identifier.citationJames, S. L. et al. 2019. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(1):56-87. doi:10.1016/S1474-4422(18)30415-0
dc.identifier.issn1474-4465 (online)
dc.identifier.issn1474-4422 (print)
dc.identifier.otherdoi:10.1016/S1474-4422(18)30415-0
dc.identifier.urihttp://hdl.handle.net/10019.1/123234
dc.language.isoen_ZAen_ZA
dc.publisherElsevier
dc.rights.holderAuthors retain rights
dc.subjectTraumatic brain injury -- Epidemiology -- 2016 A.D.en_ZA
dc.subjectBrain -- Wounds and injuries -- Epidemiology -- 2016 A.D.en_ZA
dc.subjectSpinal cord -- Wounds and injuries -- Epidemiology -- 2016 A.D.en_ZA
dc.subjectSystematic reviews (Medical research)en_ZA
dc.titleGlobal, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016en_ZA
dc.typeArticleen_ZA
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