Systems approach to the study of brain damage in the very preterm newborn

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dc.contributor.authorLeviton, Alanen_ZA
dc.contributor.authorGressens, Pierreen_ZA
dc.contributor.authorWolkenhauer, Olafen_ZA
dc.contributor.authorDammann, Olafen_ZA
dc.date.accessioned2017-08-15T10:00:56Z
dc.date.available2017-08-15T10:00:56Z
dc.date.issued2016
dc.descriptionCITATION: Leviton, A., et al. 2016. Systems approach to the study of brain damage in the very preterm newborn. Frontiers in Systems Neuroscience, 9:58, doi:10.3389/fnsys.2015.00058.
dc.descriptionThe original publication is available at http://journal.frontiersin.org
dc.description.abstractBackground: A systems approach to the study of brain damage in very preterm newborns has been lacking. Methods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena. Results: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity. Conclusions: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.en_ZA
dc.description.urihttp://journal.frontiersin.org/article/10.3389/fnsys.2015.00058/full
dc.description.versionPublisher's version
dc.format.extent12 pages
dc.identifier.citationLeviton, A., et al. 2016. Systems approach to the study of brain damage in the very preterm newborn. Frontiers in Systems Neuroscience, 9:58, doi:10.3389/fnsys.2015.00058
dc.identifier.issn1662-5137 (online)
dc.identifier.otherdoi:10.3389/fnsys.2015.00058
dc.identifier.urihttp://hdl.handle.net/10019.1/102106
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Media
dc.rights.holderAuthors retain copyright
dc.subjectBrain damage -- Pathogenesisen_ZA
dc.subjectEncephalopathyen_ZA
dc.subjectPremature infantsen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectBrain -- Molecular aspectsen_ZA
dc.titleSystems approach to the study of brain damage in the very preterm newbornen_ZA
dc.typeArticleen_ZA
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