Systems approach to the study of brain damage in the very preterm newborn
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Abstract
Background: A systems approach to the study of brain damage in very preterm newborns has been lacking.
Methods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena.
Results: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity.
Conclusions: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.
Description
CITATION: Leviton, A., et al. 2016. Systems approach to the study of brain damage in the very preterm newborn. Frontiers in Systems Neuroscience, 9:58,
doi:10.3389/fnsys.2015.00058.
The original publication is available at http://journal.frontiersin.org
The original publication is available at http://journal.frontiersin.org
Keywords
Brain damage -- Pathogenesis, Encephalopathy, Premature infants, Biochemical markers, Brain -- Molecular aspects
Citation
Leviton, A., et al. 2016. Systems approach to the study of brain damage in the very preterm newborn. Frontiers in Systems Neuroscience, 9:58,
doi:10.3389/fnsys.2015.00058