5-HT2A: Its role in frontally mediated executive function and related psychopathology

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dc.contributor.authorStein D.J.
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorMoolman-Smook H.
dc.contributor.authorAudenaert K.
dc.date.accessioned2011-05-15T16:01:24Z
dc.date.available2011-05-15T16:01:24Z
dc.date.issued2007
dc.description.abstractSerotonin (5-HT)2A receptors are widely distributed, with high levels in the frontal cortex, where postsynaptic activation may increase activity in pyramidal glutamatergic neurons and mediate various executive functions. More specifically, reciprocal cortical-raphe pathways may allow the ventral prefrontal cortex to inhibit stress-induced neural activity in the brainstem when stressors are perceived as controllable. However, early adversity and negative attitudes may be associated with higher frontal 5-HT2A receptor levels and greater risk for stress-induced psychopathology, and certain 5-HT2A gene variants have been associated with increased risk for impulsive behavior. Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders.
dc.description.versionArticle
dc.identifier.citationCNS Spectrums
dc.identifier.citation12
dc.identifier.citation7
dc.identifier.issn10928529
dc.identifier.urihttp://hdl.handle.net/10019.1/11957
dc.subjectantidepressant agent
dc.subjectglucocorticoid
dc.subjectmianserin
dc.subjectmirtazapine
dc.subjectnefazodone
dc.subjectserotonin 2A receptor
dc.subjectserotonin 2B receptor
dc.subjectserotonin 2C receptor
dc.subjectserotonin uptake inhibitor
dc.subjecttrazodone
dc.subjectallele
dc.subjectarticle
dc.subjectbinding site
dc.subjectcase report
dc.subjectclinical feature
dc.subjectdiagnostic and statistical manual of mental disorders
dc.subjectdrug mechanism
dc.subjectdrug withdrawal
dc.subjectgene expression
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjecthuman
dc.subjectimpulsiveness
dc.subjectliver toxicity
dc.subjectmale
dc.subjectmental disease
dc.subjectpessimism
dc.subjectpriority journal
dc.subjectrecurrent disease
dc.subjectrisk factor
dc.subjectsexual dysfunction
dc.subjectsignal transduction
dc.subjectsingle nucleotide polymorphism
dc.subjectupregulation
dc.subjectattitude
dc.subjectcognitive defect
dc.subjectfrontal lobe
dc.subjectmajor depression
dc.subjectmental stress
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectpositron emission tomography
dc.subjectpsychological aspect
dc.subjectAttitude
dc.subjectCognition Disorders
dc.subjectDepressive Disorder, Major
dc.subjectFrontal Lobe
dc.subjectHumans
dc.subjectMale
dc.subjectPositron-Emission Tomography
dc.subjectReceptor, Serotonin, 5-HT2A
dc.subjectSerotonin Uptake Inhibitors
dc.subjectStress, Psychological
dc.subjectTrazodone
dc.title5-HT2A: Its role in frontally mediated executive function and related psychopathology
dc.typeArticle
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