Rhinovirus is associated with severe asthma exacerbations and raised nasal interleukin-12

Simple item page
dc.contributor.authorFerreira A.
dc.contributor.authorWilliams Z.
dc.contributor.authorDonninger H.
dc.contributor.authorVan Schalkwyk E.M.
dc.contributor.authorBardin P.G.
dc.date.accessioned2011-05-15T15:57:33Z
dc.date.available2011-05-15T15:57:33Z
dc.date.issued2002
dc.description.abstractBackground: Rhinovirus (RV) is associated with asthma exacerbations in longitudinal studies, but the role in patients with acute severe asthma who require admission to a hospital emergency room remains to be fully defined. The cytokines interleukin-10 (IL-10) and IL-12 may be elevated or suppressed by viral infections and contribute to a worsening of airway inflammation in asthmatics. Objectives: We assessed the association of RV with acute severe asthma and nasal IL-10 and IL-12. Methods: Patients admitted to a hospital emergency asthma service had nasal aspirates (NAs) taken and peak expiratory flow (PEF) measured on admission and again 7, 28 and 56 days after admission. RV was sought in all NAs using a validated polymerase chain reaction assay and IL-10 and IL-12 were measured on admission and after 56 days in a subgroup of 22 asthmatics and 6 normal controls. Results: Thirty-seven asthmatics with a reduced PEF (% predicted) of 50.4 ± 2.5% (mean ± SEM) on admission were studied. RV was detected in NAs of 13 patients (35%) on admission, in 6 of the 13 patients after 7 days (16%), in 1 patient after 28 and 56 days and was absent in controls. IL-10 was not increased on admission or after 56 days. Measurements of IL-12 were raised on admission compared to 56 days later in asthmatics with RV detectable (p = 0.04). In asthmatics without RV, nasal IL-12 levels were correlated with PEF measurements over this period (r = 0.5, p < 0.05). Conclusions: A temporal relationship between the presence of nasal RV and emergency room admission for acute severe asthma was found in one third of patients. Low levels of IL-10 during RV infections could contribute to unopposed synthesis of pro-inflammatory cytokines whilst increases in IL-12 may amplify nasal and endo-bronchial inflammation. Copyright © 2002 S. Karger AG, Basel.
dc.description.versionArticle
dc.identifier.citationRespiration
dc.identifier.citation69
dc.identifier.citation2
dc.identifier.issn257931
dc.identifier.other10.1159/000056316
dc.identifier.urihttp://hdl.handle.net/10019.1/10462
dc.subjectantihistaminic agent
dc.subjectbeta 2 adrenergic receptor stimulating agent
dc.subjectcorticosteroid
dc.subjectinterleukin 10
dc.subjectinterleukin 12
dc.subjecttheophylline
dc.subjectadult
dc.subjectarticle
dc.subjectaspiration
dc.subjectasthma
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdisease exacerbation
dc.subjectemergency ward
dc.subjectfemale
dc.subjectfollow up
dc.subjecthospital admission
dc.subjecthuman
dc.subjectmale
dc.subjectpeak expiratory flow
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectRhinovirus
dc.subjectvirus detection
dc.subjectAsthma
dc.subjectHumans
dc.subjectInterleukin-10
dc.subjectInterleukin-12
dc.subjectNasal Lavage Fluid
dc.subjectPeak Expiratory Flow Rate
dc.subjectPolymerase Chain Reaction
dc.titleRhinovirus is associated with severe asthma exacerbations and raised nasal interleukin-12
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications