Blood ketone bodies and breath acetone analysis and their correlations in type 2 diabetes mellitus

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dc.contributor.authorSaasa, Valentineen_ZA
dc.contributor.authorBeukes, Mervynen_ZA
dc.contributor.authorLemmer, Yolandyen_ZA
dc.contributor.authorMwakikunga, Bonexen_ZA
dc.date.accessioned2021-09-03T10:29:59Z
dc.date.available2021-09-03T10:29:59Z
dc.date.issued2019-12-17
dc.descriptionCITATION: Saasa, V., et al., 2019. Blood ketone bodies and breath acetone analysis and their correlations in type 2 diabetes mellitus. Diagnostics, 9(4). doi:10.3390/diagnostics9040224.
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/diagnostics
dc.description.abstractAnalysis of volatile organic compounds in the breath for disease detection and monitoring has gained momentum and clinical significance due to its rapid test results and non-invasiveness, especially for diabetes mellitus (DM). Studies have suggested that breath gases, including acetone, may be related to simultaneous blood glucose (BG) and blood ketone levels in adults with types 2 and 1 diabetes. Detecting altered concentrations of ketones in the breath, blood and urine may be crucial for the diagnosis and monitoring of diabetes mellitus. This study assesses the efficacy of a simple breath test as a non-invasive means of diabetes monitoring in adults with type 2 diabetes mellitus. Human breath samples were collected in Tedlar™ bags and analyzed by headspace solid-phase microextraction and gas chromatography-mass spectrometry (HS-SPME/GC-MS). The measurements were compared with capillary BG and blood ketone levels (β-hydroxybutyrate and acetoacetate) taken at the same time on a single visit to a routine hospital clinic in 30 subjects with type 2 diabetes and 28 control volunteers. Ketone bodies of diabetic subjects showed a significant increase when compared to the control subjects; however, the ketone levels were was controlled in both diabetic and non-diabetic volunteers. Worthy of note, a statistically significant relationship was found between breath acetone and blood acetoacetate (R = 0.89) and between breath acetone and β-hydroxybutyrate (R = 0.82).en_ZA
dc.description.sponsorshipDSI-CSIR
dc.description.urihttps://www.mdpi.com/2075-4418/9/4/224#
dc.description.versionPublisher’s version
dc.format.extent10 pages
dc.identifier.citationSaasa, V., et al., 2019. Blood ketone bodies and breath acetone analysis and their correlations in type 2 diabetes mellitus. Diagnostics, 9(4). doi:10.3390/diagnostics9040224.
dc.identifier.issn2075-4418 (online)
dc.identifier.otherdoi:10.3390/diagnostics9040224
dc.identifier.urihttp://hdl.handle.net/10019.1/122990
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain rights
dc.subjectDiabetes mellitus, type 2en_ZA
dc.subjectKetone bodiesen_ZA
dc.subjectHuman breathen_ZA
dc.subjectAcetone -- Analysisen_ZA
dc.subjectBeta-hydroxybutyrateen_ZA
dc.subjectAcetoacetateen_ZA
dc.subjectGas chromatography-mass spectrometry (GC-MS)en_ZA
dc.subjectVolatile organic compounds -- Analysisen_ZA
dc.titleBlood ketone bodies and breath acetone analysis and their correlations in type 2 diabetes mellitusen_ZA
dc.typeArticleen_ZA
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