A comparative analysis of kinetic models of erythrocyte glycolysis

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dc.contributor.authordu Preez F.B.
dc.contributor.authorConradie R.
dc.contributor.authorPenkler G.P.
dc.contributor.authorHolm K.
dc.contributor.authorvan Dooren F.L.J.
dc.contributor.authorSnoep J.L.
dc.date.accessioned2011-05-15T15:59:50Z
dc.date.available2011-05-15T15:59:50Z
dc.date.issued2008
dc.description.abstractSince the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Theoretical Biology
dc.identifier.citation252
dc.identifier.citation3
dc.identifier.issn225193
dc.identifier.other10.1016/j.jtbi.2007.10.006
dc.identifier.urihttp://hdl.handle.net/10019.1/11386
dc.subject2,3 diphosphoglyceric acid
dc.subjectadenosine diphosphate
dc.subjectadenosine triphosphate
dc.subjectglutathione
dc.subjectreduced nicotinamide adenine dinucleotide phosphate
dc.subjectbiological production
dc.subjectcatabolism
dc.subjectcomparative study
dc.subjectcytology
dc.subjectglucose
dc.subjecthomeostasis
dc.subjectpeptide
dc.subjectreaction rate
dc.subjectarticle
dc.subjectcomparative study
dc.subjectconcentration (parameters)
dc.subjectenzyme activity
dc.subjecterythrocyte
dc.subjectglycolysis
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectkinetics
dc.subjectmetabolic regulation
dc.subjectnuclear magnetic resonance
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectAdenosine Triphosphate
dc.subjectErythrocytes
dc.subjectGlutathione
dc.subjectGlycolysis
dc.subjectHumans
dc.subjectModels, Cardiovascular
dc.titleA comparative analysis of kinetic models of erythrocyte glycolysis
dc.typeArticle
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