Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain

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dc.contributor.authorJohnson R.
dc.contributor.authorWarren R.M.
dc.contributor.authorVan Der Spuy G.D.
dc.contributor.authorVan Pittius N.C.G.
dc.contributor.authorTheron D.
dc.contributor.authorStreicher E.M.
dc.contributor.authorBosman M.
dc.contributor.authorCoetzee G.J.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorVictor T.C.
dc.date.accessioned2011-05-15T15:53:46Z
dc.date.available2011-05-15T15:53:46Z
dc.date.issued2010
dc.description.abstractTemporal analysis of drug-resistant tuberculosis (TB) cases in the Western Cape, South Africa, showed a 1.5-fold increase over a 2-year period, suggesting a doubling time of 8.2 years. This increase was strongly associated with multidrug resistance and the Beijing genotype. Forty-two per cent of the overall increase was due to the Beijing genotype strain R220, suggesting that this strain had evolved unique properties that allowed for both acquisition and transmission of drug resistance. To curb the drug-resistant TB epidemic in this setting, it will be essential to implement rapid diagnostics and efficient infection control measures, improve contact screening and ensure treatment adherence. ©2010 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation14
dc.identifier.citation1
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/8800
dc.titleDrug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain
dc.typeArticle
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