Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats

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dc.contributor.authorSissing L.
dc.contributor.authorMarnewick J.
dc.contributor.authorDe Kock M.
dc.contributor.authorSwanevelder S.
dc.contributor.authorJoubert E.
dc.contributor.authorGelderblom W.
dc.date.accessioned2011-10-13T16:59:05Z
dc.date.available2011-10-13T16:59:05Z
dc.date.issued2011
dc.description.abstractWidespread consumption of herbal teas has stimulated interest in their role as cancer preventive agents. The present investigation monitored the modulation of methylbenzylnitrosamine (MBN)-induced esophageal squamous cell carcinogenesis by rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) herbal and Camellia sinensis teas in male F344 rats. The tumor multiplicity was significantly (P < 0.05) inhibited by unfermented honeybush (45.5%), green (50%), and black (36%) teas, while the other teas exhibited weaker effects (<30% inhibition). The mean total papilloma size was reduced by unfermented rooibos (87%), unfermented honeybush (94%), and fermented honeybush (74%) due to the absence of large papillomas (>10 mm3). Reduction of the mean total papilloma number correlated with the total polyphenol (TPP) (r = 0.79; P < 0.02) and flavanol/proanthocyanidin (FLAVA) (r = 0.89; P < 0.008) intake (mg/100 g body weight) of the teas and the FLAVA (r = 0.89; P < 0.04) and flavonol/flavones/xanthones (r = 0.99; P < 0.002) intake when considering only the herbal teas. A daily TPP intake threshold of 7 mg/100 g body weight existed below where no inhibition of papilloma development was observed. Fermentation of herbal teas reduced the inhibitory effects on papilloma development associated with a reduction in the polyphenolic constituents. The inhibitory effect of herbal teas on papilloma development is associated with different flavonoid subgroups and/or combination thereof. Copyright © 2011, Taylor & Francis Group, LLC.
dc.description.versionArticle
dc.identifier.citationNutrition and Cancer
dc.identifier.citation63
dc.identifier.citation4
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79957594215&partnerID=40&md5=c5a06fd94886aff74b07a729e6402a22
dc.identifier.issn1635581
dc.identifier.other10.1080/01635581.2011.539313
dc.identifier.urihttp://hdl.handle.net/10019.1/16971
dc.titleModulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats
dc.typeArticle
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