Serum alpha-1-protease inhibitor activity and pulmonary function in young insulin-dependent diabetic subjects

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dc.contributor.authorSandler M.
dc.contributor.authorStewart R.I.
dc.contributor.authorGemperli B.M.
dc.contributor.authorHanekom C.
dc.contributor.authorKuhn S.H.
dc.date.accessioned2011-05-15T15:57:33Z
dc.date.available2011-05-15T15:57:33Z
dc.date.issued1987
dc.description.abstractAbnormalities of lung function have previously been described in patients with impaired α1-protease inhibitor (α1-PI) function and more recently in insulin-dependent diabetic subjects. This study was undertaken to test the hypothesis that impaired α1-PI activity may be implicated in the pathogenesis of lung function abnormalities in young insulin-dependent diabetic patients. Twelve young (16.23 ± 4.51 years), non-smoking insulin-dependent diabetic subjects and 12 reference subjects were evaluated in respect of lung mechanics, absolute serum α1-PI levels and the functional ability of α1-PI to inhibit elastase. Results of the ventilatory mechanics showed that the mean value for the volume-independent index of lung elasticity K(st)((L)) was significantly greater in the diabetic group (0.149 ± 0.05 vs. 0.116 ± 0.03; p <0.05). The absolute serum α1-PI levels in the insulin-dependent diabetic subjects was significantly lower than in reference subjects (1.74 ± 0.11 vs. 2.06 ± 0.09 g/l; p <0.05). While the specific α1-PI activity of the diabetic sera showed no significant difference from that of the reference sera, the total α1-PI inhibitory activity in the diabetic sera was significantly lower than reference values (201.9 ± 9.7 vs. 246.9 ± 13.5 U/L; p <0.02). Although these findings indicate impairment of both ventilatory mechanics and α1-PI activity in the insulin-dependent diabetic subjects, the pathogenesis of these findings and their functional implications are at present unknown.
dc.description.versionArticle
dc.identifier.citationRespiration
dc.identifier.citation52
dc.identifier.citation4
dc.identifier.issn257931
dc.identifier.urihttp://hdl.handle.net/10019.1/10469
dc.subjectalpha 1 antitrypsin
dc.subjectinsulin
dc.subjectadult
dc.subjectbreathing mechanics
dc.subjectclinical article
dc.subjectdiabetes mellitus
dc.subjecthuman
dc.subjectlung function
dc.subjectAdolescent
dc.subjectalpha 1-Antitrypsin
dc.subjectBlood Glucose
dc.subjectBlood Proteins
dc.subjectDiabetes Mellitus, Insulin-Dependent
dc.subjectHemoglobin A, Glycosylated
dc.subjectHuman
dc.subjectLung Compliance
dc.subjectLung Diseases, Obstructive
dc.subjectLung Volume Measurements
dc.subjectSupport, Non-U.S. Gov't
dc.titleSerum alpha-1-protease inhibitor activity and pulmonary function in young insulin-dependent diabetic subjects
dc.typeArticle
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