Oseltamivir use in low-birth weight infants during the 2009 nH1N1 influenza a outbreak in the Western Cape, South Africa

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dc.contributor.authorHolgate S.L.
dc.contributor.authorBekker A.
dc.contributor.authorRabie H.
dc.contributor.authorCotton M.F.
dc.date.accessioned2012-04-20T07:09:22Z
dc.date.available2012-04-20T07:09:22Z
dc.date.issued2012
dc.description.abstractBefore vaccination against nH1N1 influenza was available in South Africa our hospital experienced an outbreak of nH1N1 infection on the maternal and neonatal platform. Oseltamivir was administered to nine low birth weight infants, five for therapy and four for prophylaxis. The median gestational age was 31 (27-37) weeks and the birth weight was 1660 (720-2360) g. Respiratory function improved in those with confirmed disease and none receiving prophylaxis developed worsening respiratory symptoms. One neonate receiving prophylaxis developed self-limiting conjunctivitis; another succumbed from necrotizing enterocolitis (NEC) three days post completion of oseltamivir treatment. A causal relationship between oseltamivir and NEC, although unlikely, cannot be confirmed or excluded. © The Author [2011]. Published by Oxford University Press. All rights reserved.
dc.identifier.citationJournal of Tropical Pediatrics
dc.identifier.citation58
dc.identifier.citation2
dc.identifier.citation102
dc.identifier.citation106
dc.identifier.issn1426338
dc.identifier.other10.1093/tropej/fmr050
dc.identifier.urihttp://hdl.handle.net/10019.1/20790
dc.subjectH1N1 influenza
dc.subjectLow birth weight
dc.subjectOseltamivir
dc.titleOseltamivir use in low-birth weight infants during the 2009 nH1N1 influenza a outbreak in the Western Cape, South Africa
dc.typeArticle
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