Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model.

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dc.contributor.authorFaure J.
dc.contributor.authorUys J.D.
dc.contributor.authorMarais L.
dc.contributor.authorStein D.J.
dc.contributor.authorDaniels W.M.
dc.date.accessioned2011-05-15T15:59:58Z
dc.date.available2011-05-15T15:59:58Z
dc.date.issued2006
dc.description.abstractEarly adverse life events, followed by subsequent stressors, appear to increase susceptibility for subsequent onset of psychiatric disorders in humans. The molecular mechanisms that underlie this phenomenon remain unclear, but dysregulation of the HPA axis and alterations in neurotrophic factors have been implicated. The present study investigated the effects in rodents of early maternal separation, followed by stress in adolescence and adulthood on later HPA-axis activity and hippocampal neurotrophin levels (brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3). Animals subjected to repeated stressors showed a significant decrease in basal ACTH (p < 0.05) and CORT (p < 0.05) levels when compared to controls, as well as significantly increased levels of NGF in the dorsal (p < 0.001) and ventral hippocampus (p < 0.01), and of NT-3 in the dorsal hippocampus (p < 0.01). Dysregulation of the HPA axis after multiple stressors is consistent with previous preclinical and clinical work. Given that neurotrophins are important in neuronal survival and plasticity, it is possible to speculate that their elevation reflects a compensatory mechanism.
dc.description.versionArticle
dc.identifier.citationMetabolic brain disease
dc.identifier.citation21
dc.identifier.citation03-Feb
dc.identifier.issn8857490
dc.identifier.urihttp://hdl.handle.net/10019.1/11462
dc.subjectbrain derived neurotrophic factor
dc.subjectcorticosterone
dc.subjectcorticotropin
dc.subjectnerve growth factor
dc.subjectneurotrophin 3
dc.subjectanimal
dc.subjectarticle
dc.subjectblood
dc.subjecthippocampus
dc.subjecthypothalamus hypophysis system
dc.subjectmale
dc.subjectmaternal deprivation
dc.subjectmental stress
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectrat
dc.subjectSprague Dawley rat
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnimals
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectCorticosterone
dc.subjectHippocampus
dc.subjectHypothalamo-Hypophyseal System
dc.subjectMale
dc.subjectMaternal Deprivation
dc.subjectNerve Growth Factors
dc.subjectNeurotrophin 3
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectStress, Psychological
dc.titleEarly maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model.
dc.typeArticle
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