Quantifying histopathological alterations in the hepatopancreas of the woodlouse Porcellio laevis (Isopoda) as a biomarker of cadmium exposure

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dc.contributor.authorOdendaal J.P.
dc.contributor.authorReinecke A.J.
dc.date.accessioned2011-05-15T16:01:36Z
dc.date.available2011-05-15T16:01:36Z
dc.date.issued2003
dc.description.abstractThe aims of this study were to determine and quantify the effects of cadmium sulfate on the histological structure of the hepatopancreas of Porcellio laevis, to determine the extent of the changes due to cadmium exposure, and to assess whether these effects could serve as biomarkers of cadmium exposure. For this purpose, different batches of P. laevis were exposed for 6 weeks to shredded leaves contaminated with a range of different concentrations of cadmium sulfate. Histological sections of different parts of the hepatopancreases revealed that the exposure changed the structure of the hepatopancreas. Quantification of this change in hepatopancreas structure (expressed as the percentage cellular area or PCA) showed that there was a dose-related change in certain areas of the hepatopancreas of woodlice exposed to cadmium sulfate in comparison to those areas of unexposed controls. This change was evident despite the fact that PCA also varied over the length of the hepatopancreas in the control specimens. This study showed that PCA can be a useful measure of change in the hepatopancreas resulting from toxic stress. Although it may not be practical for regular monitoring, it could serve as a useful research tool and general biomarker in studies of toxic stress in woodlice. © 2003 Elsevier Science (USA). All rights reserved.
dc.description.versionArticle
dc.identifier.citationEcotoxicology and Environmental Safety
dc.identifier.citation56
dc.identifier.citation2
dc.identifier.issn1476513
dc.identifier.other10.1016/S0147-6513(02)00163-X
dc.identifier.urihttp://hdl.handle.net/10019.1/12061
dc.subjectcadmium sulfate
dc.subjectheavy metal
dc.subjecthistopathology
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectenvironmental monitoring
dc.subjectheavy metal poisoning
dc.subjecthistology
dc.subjecthistopathology
dc.subjectinsect
dc.subjectliver
dc.subjectliver toxicity
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectPorcellio laevis
dc.subjectquantitative analysis
dc.subjectAnimals
dc.subjectBiological Markers
dc.subjectCadmium Compounds
dc.subjectDose-Response Relationship, Drug
dc.subjectEnvironmental Exposure
dc.subjectHepatopancreas
dc.subjectIsopoda
dc.subjectSulfates
dc.subjectIsopoda
dc.subjectOniscidea
dc.subjectPorcellio
dc.subjectPorcellio laevis
dc.titleQuantifying histopathological alterations in the hepatopancreas of the woodlouse Porcellio laevis (Isopoda) as a biomarker of cadmium exposure
dc.typeArticle
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