Paediatric use of second-line anti-tuberculosis agents: A review

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dc.contributor.authorSeddon J.A.
dc.contributor.authorHesseling A.C.
dc.contributor.authorMarais B.J.
dc.contributor.authorMcIlleron H.
dc.contributor.authorPeloquin C.A.
dc.contributor.authorDonald P.R.
dc.contributor.authorSchaaf S.H.
dc.date.accessioned2012-01-18T08:06:33Z
dc.date.available2012-01-18T08:06:33Z
dc.date.issued2012-01-18
dc.descriptionPlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: scholar@sun.ac.za
dc.description.abstractChildhood multidrug-resistant tuberculosis (MDR-TB) is an emerging global epidemic. With the imminent roll-out of rapid molecular diagnostic tests, more children are likely to be identified and require treatment. As MDR-TB is resistant to the most effective first-line drugs, clinicians will have to rely on second-line medications which are less effective and often associated with more pronounced adverse effects than first-line therapy. Despite the fact that most of these agents were discovered many years ago, robust information is lacking regarding their pharmacokinetic and pharmacodynamic properties, adverse effects and drug interactions, especially in children. Children differ from adults in the way that drugs are administered, the manner in which they are metabolised and in the adverse effects experienced. The interaction of these drugs with human immunodeficiency virus infection and antiretroviral therapy is also poorly documented. This article reviews the available second-line drugs currently used in the treatment of MDR-TB in children and discusses medication properties and adverse effects while potential interactions with antiretroviral therapy are explored.
dc.identifier.citationTuberculosis
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-81555236543&partnerID=40&md5=772d80d5a64c1a492540d4f8636f79d3
dc.identifier.issn14729792
dc.identifier.other10.1016/j.tube.2011.11.001
dc.identifier.urihttp://hdl.handle.net/10019.1/19098
dc.titlePaediatric use of second-line anti-tuberculosis agents: A review
dc.typeArticle in Press
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