Single Photon Emission Computed Tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol

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dc.contributor.authorCarey P.D.
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorHarvey B.H.
dc.contributor.authorStein D.J.
dc.contributor.authorSeedat S.
dc.date.accessioned2011-05-15T15:59:59Z
dc.date.available2011-05-15T15:59:59Z
dc.date.issued2004
dc.description.abstractInositol, a glucose isomer and second messenger precursor, regulates numerous cellular functions and has demonstrated efficacy in obsessive-compulsive disorder (OCD) through mechanisms that remain unclear. The effect of inositol treatment on brain function in OCD has not been studied to date. Fourteen OCD subjects underwent single photon emission computed tomography (SPECT) with Tc-99m HMPAO before and after 12 weeks of treatment with inositol. Whole brain voxel-wise SPM was used to assess differences in perfusion between responders and nonresponders before and after treatment as well as the effect of treatment for the group as a whole. There was 1) deactivation in OCD responders relative to nonresponders following treatment with inositol in the left superior temporal gyrus, middle frontal gyrus and precuneus, and the right paramedian post-central gyrus; 2) no significant regions of deactivation for the group as a whole posttreatment; and 3) a single cluster of higher perfusion in the left medial prefrontal region in responders compared to nonresponders at baseline. Significant reductions in the YBOCS and CGI - severity scores followed treatment. These data are only partly consistent with previous functional imaging work on OCD. They may support the idea that inositol effects a clinical response through alternate neuronal circuitry to the SSRIs and may complement animal work proposing an overlapping but distinct mechanism of action.
dc.description.versionConference Paper
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation19
dc.identifier.citation02-Jan
dc.identifier.issn8857490
dc.identifier.other10.1023/B:MEBR.0000027423.34733.12
dc.identifier.urihttp://hdl.handle.net/10019.1/11466
dc.subjectinositol
dc.subjectserotonin uptake inhibitor
dc.subjecttechnetium 99m
dc.subjectdiagnostic agent
dc.subjecthexamethylpropylene amine oxime technetium tc 99m
dc.subjectradiopharmaceutical agent
dc.subjectabdominal cramp
dc.subjectadult
dc.subjectbrain function
dc.subjectbrain region
dc.subjectclinical article
dc.subjectconference paper
dc.subjectcontrolled study
dc.subjectdiarrhea
dc.subjectdisease severity
dc.subjectdizziness
dc.subjectdrug safety
dc.subjectdrug tolerability
dc.subjectfatigue
dc.subjectfemale
dc.subjectflatulence
dc.subjectheadache
dc.subjecthuman
dc.subjectincreased appetite
dc.subjectlethargy
dc.subjectmale
dc.subjectnausea
dc.subjectneuroimaging
dc.subjectObsessive-compulsive disorderen_ZA
dc.subjectperfusion
dc.subjectscoring system
dc.subjectside effect
dc.subjectsingle photon emission computer tomography
dc.subjectstatistical significance
dc.subjectarticle
dc.subjectbrain circulation
dc.subjectclinical trial
dc.subjectcomparative study
dc.subjectscintiscanning
dc.subjectAnimalia
dc.subjectCerebrovascular Circulation
dc.subjectFemale
dc.subjectHumans
dc.subjectInositol
dc.subjectMale
dc.subjectObsessive-Compulsive Disorder
dc.subjectRadiopharmaceuticals
dc.subjectTechnetium Tc 99m Exametazime
dc.subjectTomography, Emission-Computed, Single-Photon
dc.titleSingle Photon Emission Computed Tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol
dc.typeConference Paper
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