Cardiac dysrhythmias associated with intravenous lorazepam, diazepam, and midazolam during oral surgery

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dc.contributor.authorRoelofse J.A.
dc.contributor.authorVan der Bijl P.
dc.date.accessioned2011-05-15T16:02:01Z
dc.date.available2011-05-15T16:02:01Z
dc.date.issued1994
dc.description.abstractThe incidence and nature of cardiac dysrhythmias occurring during intravenous sedation with lorazepam, diazepam, and midazolam for oral surgery were studied. Sixty American Society of Anesthesiologists (ASA) I patients of both sexes between the ages 17 and 32 years were randomly allocated to three groups. Groups received either intravenous lorazepam (.05 mg/kg), diazepam (.25 mg/kg), or midazolam (.1 mg/kg) prior to the oral surgical procedure. Electrocardiograms were made before medication and thereafter throughout the entire procedure. Of the 60 patients studied, 16 (26.7%) exhibited dysrhythmias during the surgical procedure. If sinus dysrhythmias were excluded as a cause of abnormal rhythms, only six patients (10%) exhibited dysrhythmias during surgery. No atrial or ventricular premature beats were recorded for the lorazepam group. In the diazepam group five of the patients (25%) exhibited dysrhythmias; 15% were mainly unifocal ventricular premature beats. Only one patient in the midazolam group exhibited unifocal ventricular premature beats.
dc.description.versionArticle
dc.identifier.citationJournal of Oral and Maxillofacial Surgery
dc.identifier.citation52
dc.identifier.citation3
dc.identifier.issn2782391
dc.identifier.urihttp://hdl.handle.net/10019.1/12265
dc.subjectdiazepam
dc.subjectlorazepam
dc.subjectmidazolam
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectbradycardia
dc.subjectclinical trial
dc.subjectdental anesthesia
dc.subjectdental surgery
dc.subjectelectrocardiography monitoring
dc.subjectfemale
dc.subjectheart arrhythmia
dc.subjectheart ventricle extrasystole
dc.subjecthuman
dc.subjectintraoperative period
dc.subjectintravenous drug administration
dc.subjectlocal anesthesia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoral surgery
dc.subjectpatient monitoring
dc.subjectsupraventricular premature beat
dc.subjecttachycardia
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectAnesthesia, Dental
dc.subjectAnti-Anxiety Agents, Benzodiazepine
dc.subjectArrhythmia
dc.subjectComparative Study
dc.subjectConscious Sedation
dc.subjectDiazepam
dc.subjectFemale
dc.subjectHuman
dc.subjectLorazepam
dc.subjectMale
dc.subjectMidazolam
dc.subjectMolar, Third
dc.subjectTooth Extraction
dc.titleCardiac dysrhythmias associated with intravenous lorazepam, diazepam, and midazolam during oral surgery
dc.typeArticle
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