Hepatitis B sero-prevalence in children under 15 years of age in South Africa using residual samples from community-based febrile rash surveillance

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dc.contributor.authorPrabdial-Sing, Nishien_ZA
dc.contributor.authorMakhathini, Lillianen_ZA
dc.contributor.authorSmit, Sheilagh Brigitteen_ZA
dc.contributor.authorManamela, Morubula Jacken_ZA
dc.contributor.authorMotaze, Nkengafac Villyenen_ZA
dc.contributor.authorCohen, Cherylen_ZA
dc.contributor.authorSuchard, Melinda Shelleyen_ZA
dc.date.accessioned2021-10-25T12:25:43Z
dc.date.available2021-10-25T12:25:43Z
dc.date.issued2019-05-31
dc.descriptionCITATION: Prabdial-Sing, N. et al. 2019. Hepatitis B sero-prevalence in children under 15 years of age in South Africa using residual samples from community-based febrile rash surveillance. PLoS ONE, 14(5). doi:10.1371/journal.pone.0217415
dc.descriptionThe original publication is available at https://journals.plos.org/plosone/
dc.description.abstractIntroduction and methods: Hepatitis B is a vaccine preventable disease and is notifiable in South Africa. Hepatitis B vaccination was incorporated into the Expanded Programme on Immunisation in South Africa in 1995. We used a convenience sample from community-based febrile rash surveillance in 2013 to estimate hepatitis B sero-prevalence. Of samples serologically negative for acute measles infection, 450 samples spanning nine provinces of South Africa were tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs) and hepatitis B core antibody (anti-HBc). Results: Two children (2/450; 0.4%) tested positive for HBsAg. Three hundred and three children (67.3%) had evidence of vaccine induced immunity. Vaccine induced immunity was present in 80.2% of 1–5 year olds, but only 60.3% of 10–14 year olds. Natural immunity, indicating exposure to circulating hepatitis B, was present in 13/450 (2.9%) children. Conclusion: Chronic hepatitis B in South African has decreased in prevalence from highly endemic levels prior to vaccine introduction to approximately 0.4% in this sample, demonstrating impact of a successful vaccination programme 18 years after introduction. Decreased vaccine-induced immunity with increasing age may reflect waning antibody titres over time.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217415
dc.description.versionPublisher's version
dc.format.extent9 pages
dc.identifier.citationPrabdial-Sing, N. et al. 2019. Hepatitis B sero-prevalence in children under 15 years of age in South Africa using residual samples from community-based febrile rash surveillance. PLoS ONE, 14(5). doi:10.1371/journal.pone.0217415
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0217415
dc.identifier.urihttp://hdl.handle.net/10019.1/123309
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain rights
dc.subjectHepatitis B -- Children -- Incidence -- South Africaen_ZA
dc.subjectHepatitis B -- Serodiagnosis -- South Africaen_ZA
dc.subjectHepatitis B -- Immunological aspects -- South Africaen_ZA
dc.subjectFever in children -- Examinationen_ZA
dc.titleHepatitis B sero-prevalence in children under 15 years of age in South Africa using residual samples from community-based febrile rash surveillanceen_ZA
dc.typeArticleen_ZA
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