Human whole genome sequencing in South Africa

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dc.contributor.authorGlanzmann, Brigitteen_ZA
dc.contributor.authorJooste, Traceyen_ZA
dc.contributor.authorGhoor, Samiraen_ZA
dc.contributor.authorGordon, Richarden_ZA
dc.contributor.authorMia, Rizwanaen_ZA
dc.contributor.authorMao, Junen_ZA
dc.contributor.authorLi, Haoen_ZA
dc.contributor.authorCharls, Patricken_ZA
dc.contributor.authorDouman, Craigen_ZA
dc.contributor.authorKotze, Maritha J.en_ZA
dc.contributor.authorPeeters, Armand V.en_ZA
dc.contributor.authorLoots, Glaudinaen_ZA
dc.contributor.authorEsser, Monikaen_ZA
dc.contributor.authorTiemessen, Caroline T.en_ZA
dc.contributor.authorWilkinson, Robert J.en_ZA
dc.contributor.authorLouw, Johanen_ZA
dc.contributor.authorGray, Glendaen_ZA
dc.contributor.authorWarren, Robin M.en_ZA
dc.contributor.authorMoller, Marloen_ZA
dc.contributor.authorKinnear, Craigen_ZA
dc.date.accessioned2023-04-05T11:45:01Zen_ZA
dc.date.available2023-04-05T11:45:01Zen_ZA
dc.date.issued2021-01en_ZA
dc.descriptionCITATION: Glanzmann, B. et al. 2021. Human whole genome sequencing in South Africa. Scientific Reports, 11:606, doi:10.1038/s41598-020-79794-x.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.description.abstractThe advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council’s Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-020-79794-xen_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent8 pagesen_ZA
dc.identifier.citationGlanzmann, B. et al. 2021. Human whole genome sequencing in South Africa. Scientific Reports, 11:606, doi:10.1038/s41598-020-79794-x.en_ZA
dc.identifier.issn2045-2322 (online)en_ZA
dc.identifier.otherdoi:10.1038/s41598-020-79794-xen_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126772en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherNatureen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectNucleotide sequence -- South Africaen_ZA
dc.subjectHuman genome -- South Africaen_ZA
dc.subjectHigh-throughput nucleotide sequencingen_ZA
dc.titleHuman whole genome sequencing in South Africaen_ZA
dc.typeArticleen_ZA
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