Early maternal separation alters the response to traumatization: Resulting in increased levels of hippocampal neurotrophic factors

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dc.contributor.authorFaure J.
dc.contributor.authorUys J.D.K.
dc.contributor.authorMarais L.
dc.contributor.authorStein D.J.
dc.contributor.authorDaniels W.M.U.
dc.date.accessioned2011-05-15T15:59:58Z
dc.date.available2011-05-15T15:59:58Z
dc.date.issued2007
dc.description.abstractEarly life adversity predisposes individuals to the development of psychopathology in later life, especially depression and anxiety disorders. Prior history of stressors may also be a vulnerability factor for developing posttraumatic stress disorder (PTSD) in response to trauma. We examined the mechanisms underlying this phenomenon by employing two animal stress models, early maternal separation followed by later time-dependent sensitization (TDS). In animals exposed to adult TDS, those with prior early adversity did not differ from controls on tests of anxiety (elevated plus maze, open field), or HPA function (ACTH and corticosterone levels). However, those with prior early adversity had increased levels of neurotrophic factors (BDNF, NGF and NT-3) in both the dorsal and ventral hippocampus. Although early adversity is known to be associated with negative effects on neuronal function, it may also be associated with an increased ability to respond to subsequent stressors with compensatory mechanisms such as increased neurotrophic factor release. © 2007 Springer Science+Business Media, LLC.
dc.description.versionArticle
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation22
dc.identifier.citation2
dc.identifier.issn8857490
dc.identifier.other10.1007/s11011-007-9048-3
dc.identifier.urihttp://hdl.handle.net/10019.1/11459
dc.subjectbrain derived neurotrophic factor
dc.subjectcorticosterone
dc.subjectcorticotropin
dc.subjectnerve growth factor
dc.subjectneurotrophic factor
dc.subjectneurotrophin 3
dc.subjectanimal experiment
dc.subjectanxiety
dc.subjectarticle
dc.subjectbehavior
dc.subjectcontrolled study
dc.subjecthippocampus
dc.subjecthypothalamus hypophysis adrenal system
dc.subjectinjury
dc.subjectlife stress
dc.subjectmale
dc.subjectmaternal deprivation
dc.subjectmaze test
dc.subjectnerve function
dc.subjectnonhuman
dc.subjectopen field test
dc.subjectrat
dc.subjectsensitization
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnimals
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectCorticosterone
dc.subjectHippocampus
dc.subjectHypothalamo-Hypophyseal System
dc.subjectMale
dc.subjectMaternal Deprivation
dc.subjectMaze Learning
dc.subjectNerve Growth Factor
dc.subjectNerve Growth Factors
dc.subjectNeurotrophin 3
dc.subjectPituitary-Adrenal System
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectStress, Psychological
dc.subjectAnimalia
dc.titleEarly maternal separation alters the response to traumatization: Resulting in increased levels of hippocampal neurotrophic factors
dc.typeArticle
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