Antiretroviral and Antituberculosis therapy in HIV-TB co-infected children

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dc.contributor.authorSlogrove, Amy L.en_ZA
dc.contributor.authorRabie H.
dc.contributor.authorCotton M.F.
dc.date.accessioned2011-10-13T16:58:20Z
dc.date.available2011-10-13T16:58:20Z
dc.date.issued2011
dc.description.abstractHIV-infected children experience a high burden of tuberculosis. With recent advances in international pediatric HIV treatment guidelines significant numbers of infants and children will require simultaneous treatment for both TB and HIV. This article attempts to concisely outline strategies for effective co-treatment of both infections. Rifamycins, an essential component of short course TB chemotherapy, alter the metabolism of a number of antiretroviral drugs. These interactions and their consequences are considered. Options for antiretroviral therapy and the optimal timing of its initiation in the presence of antituberculosis therapy are discussed. © 2011 Bentham Science Publishers Ltd.
dc.description.versionReview
dc.identifier.citationCurrent Pediatric Reviews
dc.identifier.citation7
dc.identifier.citation3
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79961152834&partnerID=40&md5=4c2db3358a14ed7e60561e9cf1489aa6
dc.identifier.issn15733963
dc.identifier.other10.2174/157339611796548474
dc.identifier.urihttp://hdl.handle.net/10019.1/16685
dc.subjectAntiretroviral therapy
dc.subjectAntituberculosis therapy
dc.subjectChildren
dc.subjectTB-HIV co-infection
dc.subjectabacavir
dc.subjectcotrimoxazole
dc.subjectdidanosine
dc.subjectefavirenz
dc.subjectethambutol
dc.subjectisoniazid
dc.subjectlopinavir
dc.subjectnevirapine
dc.subjectproteinase inhibitor
dc.subjectpyrazinamide
dc.subjectpyridoxine
dc.subjectrifabutin
dc.subjectrifampicin
dc.subjectrifamycin
dc.subjectrifapentine
dc.subjectritonavir
dc.subjectstavudine
dc.subjectstreptomycin
dc.subjectzidovudine
dc.subjectanemia
dc.subjectcentral nervous system disease
dc.subjectcombination chemotherapy
dc.subjectdrug blood level
dc.subjectdrug clearance
dc.subjectdrug dose escalation
dc.subjectdrug efficacy
dc.subjectdrug metabolism
dc.subjectdrug safety
dc.subjectdrug tolerance
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectliver toxicity
dc.subjectmixed infection
dc.subjectnausea and vomiting
dc.subjectneutropenia
dc.subjectoutcome assessment
dc.subjectpediatrics
dc.subjectperipheral neuropathy
dc.subjectpriority journal
dc.subjectrash
dc.subjectrecommended drug dose
dc.subjectreview
dc.subjecttreatment indication
dc.subjecttuberculosis
dc.titleAntiretroviral and Antituberculosis therapy in HIV-TB co-infected children
dc.typeReview
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