Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats

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dc.contributor.authorLouw, Ann
dc.contributor.authorSwart, P.
dc.date.accessioned2012-02-09T15:18:41Z
dc.date.issued1999-05
dc.descriptionThe original publication is available at http://endo.endojournals.org
dc.description.abstractSalsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a more stable analog, compound A, inhibits sheep adrenal cytochrome P450c11. In addition, compound A has been shown to bind to and be stabilized by corticosteroid-binding globulin (CBG). Binding may result in concomitant displacement of endogenous steroids, which could contribute to the biological effects of these compounds. The present study was undertaken to establish which mechanism would predominate in female rats. Compound A significantly (P,0.01) displaced glucocorticoids, but not progesterone, from corticosterone in both S. tuberculatiformis (P , 0.05)- and compound A (P , 0.01)-treated rats was also significantly higher due to displacement from CBG. In addition, both ACTH and CBG concentrations were significantly (P , 0.05) lower than control values. The levels of the gonadotropins were also reduced during treatment, but only LH values significantly (P , 0.05) so. These results suggest that binding of the test substances to CBG in female rat plasma and concomitant displacement of endogenous corticosterone could be part of the contraceptive mechanism of S. tuberculatiformis and the aziridine precursor, compound A.en_ZA
dc.description.versionPublishers' versionen_ZA
dc.embargo.lift2050-12-31
dc.embargo.terms2050-12-31en_ZA
dc.identifier.citationLouw, A. & Swart, P. 1999. Salsola tuberculatiformis Botschantzev and an Aziridine precursor analog mediate the in vivo increase in free Corticosterone and decrease in Corticosteroid-binding globulin in female wistar rats. Endocrinology, 140(5), 2044-2053, doi:10.1210/en.140.5.2044.
dc.identifier.issn1945-7170 (online)
dc.identifier.issn0013-7227 (print)
dc.identifier.otherdoi:10.1210/en.140.5.2044
dc.identifier.urihttp://hdl.handle.net/10019.1/19694
dc.publisherThe Endocrine Societyen_ZA
dc.rights.holderThe Endocrine Societyen_ZA
dc.subjectGlucocorticoidsen_ZA
dc.subjectCytochrome P-450en_ZA
dc.subjectGlobulinsen_ZA
dc.subjectSteroid-binding proteinsen_ZA
dc.subjectSteroid hormonesen_ZA
dc.subjectAdrenocortical hormonesen_ZA
dc.subjectRats -- Physiologyen_ZA
dc.titleSalsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar ratsen_ZA
dc.typeArticleen_ZA
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