Primate endocrine function after pancreatico-duodenal-splenic allotransplantation

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dc.contributor.authorDu Toit, D. F.
dc.contributor.authorHeydenrych, J. J.
dc.contributor.authorSmit, B.
dc.contributor.authorLouw, G.
dc.contributor.authorZuurmond, T.
dc.contributor.authorEls, D.
dc.contributor.authorWeideman, A.
dc.contributor.authorWolfe-Coote, S.
dc.contributor.authorDu Toit, L.
dc.contributor.authorGonin, R.
dc.contributor.authorDavids, H.
dc.date.accessioned2011-05-15T16:05:05Z
dc.date.available2011-05-15T16:05:05Z
dc.date.issued1987
dc.description.abstractIn this study the endocrine function following intraperitoneal hetero- and orthotopic pancreatico-duodenal-splenic allotransplantation (PDS) in hemipancreatectomized, non-immune-suppressed chacma baboons was assessed. Significantly reduced K-values and insulin release together with glucose intolerance during IVGTT were observed in hemipancreatectomized recipients (HPS) without grafts. Orthopic and heterotopic PDS transplantation improved the glucose intolerance of HPS recipients; orthotopically sited grafts rendering the best curves. Normal glucose tolerance was not achieved. Both orthotopic and heterotopic PDS transplantation rendered suboptimal insulin release during IVGTT; heterotopically draining grafts released signifcantly more insulin than orthotopic grafts. Hyperglucagonaemia during IVGTT was a constant feature in both groups, Heterotopic grafts releasing the most glucagon during stimulation. C-peptide release was significantly lower in orthotopic grafts compared to normal animals or heterotopically drained insulin. It is concluded that glucose tolerance was not directly related to insulin or glucagon release in this study as orthotopic grafts rendered near-normal IVGTT curves in the presence of hypoinsulinaemia, hyperglucagonaemia, and reduced C-peptide values. The hormonal response after PDS transplantation was variable and the advantages of portal vs systemic insulin drainage remain to be defined.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation36
dc.identifier.citation2
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12966
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectape
dc.subjectbaboon
dc.subjectduodenum transplantation
dc.subjectendocrine system
dc.subjectglucose tolerance
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectpancreas islet function
dc.subjectpancreas resection
dc.subjectpancreas transplantation
dc.subjectperitoneum
dc.subjectsmall intestine
dc.subjectspleen
dc.subjectspleen transplantation
dc.subjectAnimal
dc.subjectDuodenum
dc.subjectFemale
dc.subjectGlucagon
dc.subjectGlucose Tolerance Test
dc.subjectInsulin
dc.subjectMale
dc.subjectPancreas Transplantation
dc.subjectPapio
dc.subjectSpleen
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransplantation, Homologous
dc.titlePrimate endocrine function after pancreatico-duodenal-splenic allotransplantation
dc.typeArticle
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